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Introduction

Dr. Yoshifumi Uwamino is a distinguished researcher specializing in diagnostic assay development, with a focus on infectious diseases like COVID-19 and tuberculosis. His work includes developing PCR systems, evaluating vaccine responses, and identifying biomarkers for disease activity, contributing significantly to public health advancements.

Achievements

■Diagnostic Assay Development
・Research Objective: To investigate the quantification ability of a smartphone-based application for SARS-CoV-2-specific antibodies using lateral flow assay kits.
- Title: The utility of smartphone-based quantitative analysis of SARS-CoV-2-specific antibody lateral flow assays, Uwamino Yoshifumi, Tanaka Shiho, Shibata Ayako, Kurafuji Toshinobu, Ishihara Hideki, Sato Yasunori, Matsushita Hiromichi （Diagnostic Microbiology and Infectious Disease） 108 （ 3 ） 116166 Mar. 2024
・Research Objective: To compare the minimum inhibitory concentrations of amikacin for pulmonary Mycobacterium avium complex disease using different culture media.
- Title: Comparing minimum inhibitory concentrations of amikacin for pulmonary Mycobacterium avium complex disease: An analysis of culture media differences, Morita Atsuho, Namkoong Ho, Uwamino Yoshifumi, Mitarai Satoshi, Aono Akio, Asakura Takanori, Yagi Kazuma, Tanaka Hiromu, Azekawa Shuhei, Nakagawara Kensuke, Kaji Masanori, Nagao Genta, Kamata Hirofumi, Matsushita Hiromichi, Fukunaga Koichi, Hasegawa Naoki （Journal of Infection and Chemotherapy） 30 （ 2 ） 159-163 Feb. 2024
・Research Objective: To design and implement a collaborative PCR testing system at a medical school using a systems engineering approach during the COVID-19 pandemic.
- Title: Using a Systems Engineering Approach to Build a PCR Testing System at a Medical School During the COVID-19 Pandemic, Oba Junna, Toriya Masako, Uwamino Yoshifumi, Matsuo Koichi （Risk Management and Healthcare Policy） Volume 17 649-662 Mar. 2024
■Clinical Practice Evaluation
・Research Objective: To investigate the cost-effectiveness of universal preoperative screening of asymptomatic patients for SARS-CoV-2 using polymerase chain reaction testing.
- Title: Cost-Effectiveness of Universal Asymptomatic Preoperative SARS-CoV-2 Polymerase Chain Reaction Screening: A Cost-Utility Analysis, Uno Shunsuke, Goto Rei, Honda Kimiko, Uchida Sho, Uwamino Yoshifumi, Namkoong Ho, Yoshifuji Ayumi, Mikita Kei, Takano Yaoko, Matsumoto Morio, Kitagawa Yuko, Hasegawa Naoki （Clinical Infectious Diseases） 78 （ 1 ） 57-64 Jan. 2024
・Research Objective: To evaluate the effect of a SARS-CoV-2 booster vaccination in hemodialysis and peritoneal dialysis patients based on antibody titers and cellular and humoral immunity.
- Title: Cellular and humoral immune responses to COVID-19 booster vaccination in Japanese dialysis patients, Yoshifuji Ayumi, Toda Masataro, Oyama Emi, Nakayama Tetsuo, Mise-Omata Setsuko, Kikuchi Kan, Yoshizawa Mamoru, Kato Naohiko, Wakai Haruki, Koibuchi Kiyoto, Morimoto Kohkichi, Uwamino Yoshifumi, Namkoong Ho, Shibata Ayako, Wakabayashi Kaoru, Fujino Motoko, Komatsu Motoaki, Mochizuki Naoki, Kondo Norihiko, Yoshimura Akihiko, Hasegawa Naoki, Ryuzaki Munekazu （Clinical and Experimental Nephrology） 28 （ 7 ） 674-682 Jul. 2024
・Research Objective: To investigate the minimum inhibitory concentrations of azithromycin and clarithromycin for Mycobacterium avium complex strains isolated in Japan and examine the correlation between azithromycin MICs and treatment effectiveness.
- Title: Minimum inhibitory concentrations of azithromycin in clinical isolates of
Mycobacterium avium complex in Japan, Uwamino Yoshifumi, Aoki Wataru, Inose Rika, Kamoshita Yuka, Mikita Kei, Namkoong Ho, Nishimura Tomoyasu, Matsushita Hiromichi, Hasegawa Naoki （Microbiology Spectrum） 12 （ 6 ） Jun. 2024
- URL: https://doi.org/10.1128/spectrum.00218-24 Minimum inhibitory concentrations of azithromycin in clinical isolates of Mycobacterium avium complex in Japan
■Other
・Research Objective: To assess the seroprevalence of SARS-CoV-2 N antibodies in Japan before and after the emergence of omicron variants.
- Title: Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan, Yamayoshi Seiya, Nagai Etsuko, Mitamura Keiko, Hagihara Masao, Kobayashi Ryo, Takahashi Satoshi, Shibata Akimichi, Uwamino Yoshifumi, Hasegawa Naoki, Iqbal Asef, Kamimaki Isamu, Iwatsuki-Horimoto Kiyoko, Nagamura-Inoue Tokiko, Kawaoka Yoshihiro （Epidemiology and Infection） 152
・Research Objective: To clarify the motivations for receiving booster vaccines among Japanese university students and staff.
- Title: Factors affecting motivation for receiving a booster dose of the COVID-19 vaccine among Japanese university students and staff: a cross-sectional questionnaire survey, Uchida Sho, Uno Shunsuke, Kondo Masahiro, Uwamino Yoshifumi, Namkoong Ho, Nishimura Tomoyasu, Misawa Kana, Kashimura Shoko, Yamato Kei, Ishizaka Tamami, Nagashima Kengo, Kitagawa Yuko, Hasegawa Naoki （Scientific Reports） 14 （ 1 ） Apr. 2024
・Research Objective: To formulate a two-compartment-based mathematical model to describe the dynamics of anti-SARS-CoV-2 antibody waning in vaccinated individuals and validate it using data from healthcare providers and elderly patients.
- Title: Estimating immunity with mathematical models for SARS-CoV-2 after COVID-19 vaccination, Sato Yasunori, Uwamino Yoshifumi, Nagashima Kengo, Yoshifuji Ayumi, Suga Shigeru, Nagao Mizuho, Fujisawa Takao, Ryuzaki Munekazu, Takemoto Yoshiaki, Namkoong Ho, Wakui Masatoshi, Matsushita Hiromichi, Hasegawa Naoki, Murata Mitsuru （）

Areas of Research

・Diagnostic Assay Development
・Clinical Practice Evaluation
・Sexuality Studies
・Other

Social Contributions

・Improved disease prevention and treatment for postmenopausal women by monitoring sex steroid hormone levels, particularly estradiol, which could help in managing nontuberculous mycobacterial lung disease.
・Enhanced reliability of tuberculosis testing in women, as the menstrual cycle does not affect the results of interferon-gamma release assays (IGRA), ensuring consistent and accurate diagnosis.
Video

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