Introduction

We aim to acquire insights that lead to the elucidation of the mechanisms of respiratory diseases, particularly respiratory malignancies such as lung cancer, and the development of new treatments.

■Mechanism Elucidation
・Research Objective: To investigate the role of FGF9 upregulation in the transdifferentiation of lung adenocarcinoma to small cell lung cancer.
- Title: Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer, Ishioka Kota, Yasuda Hiroyuki, Hamamoto Junko, Terai Hideki, Emoto Katsura, Kim Tae-Jung, Hirose Shigemichi, Kamatani Takashi, Mimaki Sachiyo, Arai Daisuke, Ohgino Keiko, Tani Tetsuo, Masuzawa Keita, Manabe Tadashi, Shinozaki Taro, Mitsuishi Akifumi, Ebisudani Toshiki, Fukushima Takahiro, Ozaki Mari, Ikemura Shinnosuke, Kawada Ichiro, Naoki Katsuhiko, Nakamura Morio, Ohtsuka Takashi, Asamura Hisao, Tsuchihara Katsuya, Hayashi Yuichiro, Hegab Ahmed E., Kobayashi Susumu S., Kohno Takashi, Watanabe Hideo, Ornitz David M., Betsuyaku Tomoko, Soejima Kenzo, Fukunaga Koichi （Cancer Research） 81 （ 14 ） 3916-3929 Jul. 2021
・Research Objective: To evaluate the effectiveness of nasal delivery of a camelid single-domain antibody in improving symptoms of SARS-CoV-2 infection in an animal model.
- Title: Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model, Haga Kei, Takai-Todaka Reiko, Matsumura Yuta, Song Chihong, Takano Tomomi, Tojo Takuto, Nagami Atsushi, Ishida Yuki, Masaki Hidekazu, Tsuchiya Masayuki, Ebisudani Toshiki, Sugimoto Shinya, Sato Toshiro, Yasuda Hiroyuki, Fukunaga Koichi, Sawada Akihito, Nemoto Naoto, Murata Kazuyoshi, Morimoto Takuya, Katayama Kazuhiko （PLOS Pathogens） 17 （ 10 ） e1009542 Oct. 2021
・Research Objective: To investigate the monomer preference of EGFR tyrosine kinase inhibitors and its influence on the synergistic efficacy of combination therapy with cetuximab in EGFR-mutated lung cancer.
- Title: Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab, Oashi Ayano, Yasuda Hiroyuki, Kobayashi Keigo, Tani Tetsuo, Hamamoto Junko, Masuzawa Keita, Manabe Tadashi, Terai Hideki, Ikemura Shinnosuke, Kawada Ichiro, Naoki Katsuhiko, Soejima Kenzo （Molecular Cancer Therapeutics） 18 （ 9 ） 1593-1601 Sep. 2019
■Pathway Identification
・Research Objective: To understand the mechanism of anticancer drug resistance in KRAS-mutated lung cancer and develop new targeted therapies.
- Title: Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model, Kobayashi Keigo, Terai Hideki, Yasuda Hiroyuki, Hamamoto Junko, Hayashi Yuichiro, Takeuchi Osamu, Mitsuishi Yoichiro, Masuzawa Keita, Manabe Tadashi, Ikemura Shinnosuke, Kawada Ichiro, Suzuki Yukio, Soejima Kenzo, Fukunaga Koichi （Biochemical and Biophysical Research Communications） 534 1-7 Jan. 2021
・Research Objective: To investigate the IGF2 autocrine-mediated IGF1R activation as a nongenetic mechanism of osimertinib resistance in lung cancer.
- Title: IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer, Manabe Tadashi, Yasuda Hiroyuki, Terai Hideki, Kagiwada Harumi, Hamamoto Junko, Ebisudani Toshiki, Kobayashi Keigo, Masuzawa Keita, Ikemura Shinnosuke, Kawada Ichiro, Hayashi Yuichiro, Fukui Kazuhiko, Horimoto Katsuhisa, Fukunaga Koichi, Soejima Kenzo （Molecular Cancer Research） 18 （ 4 ） 549-559 Apr. 2020
・Research Objective: To investigate the role of EGFR wild-type allele amplification in conferring acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells.
- Title: Amplification of EGFR Wild-Type Alleles in Non–Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors, Nukaga Shigenari, Yasuda Hiroyuki, Tsuchihara Katsuya, Hamamoto Junko, Masuzawa Keita, Kawada Ichiro, Naoki Katsuhiko, Matsumoto Shingo, Mimaki Sachiyo, Ikemura Shinnosuke, Goto Koichi, Betsuyaku Tomoko, Soejima Kenzo （Cancer Research） 77 （ 8 ） 2078-2089 Apr. 2017
■Translational Research System Construction
・Research Objective: To identify the Wnt dependency in lung adenocarcinoma defined by NKX2-1 through genotype-phenotype mapping of a patient-derived lung cancer organoid biobank.
- Title: Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma, Ebisudani Toshiki, Hamamoto Junko, Togasaki Kazuhiro, Mitsuishi Akifumi, Sugihara Kai, Shinozaki Taro, Fukushima Takahiro, Kawasaki Kenta, Seino Takashi, Oda Mayumi, Hanyu Hikaru, Toshimitsu Kohta, Emoto Katsura, Hayashi Yuichiro, Asakura Keisuke, Johnson Todd A., Terai Hideki, Ikemura Shinnosuke, Kawada Ichiro, Ishii Makoto, Hishida Tomoyuki, Asamura Hisao, Soejima Kenzo, Nakagawa Hidewaki, Fujii Masayuki, Fukunaga Koichi, Yasuda Hiroyuki, Sato Toshiro （Cell Reports） 42 （ 3 ） 112212 Mar. 2023
・Research Objective: Establishment of a biobank of neuroendocrine neoplasm organoids to enable genotype-phenotype mapping.
- Title: An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping, Kawasaki Kenta, Toshimitsu Kohta, Matano Mami, Fujita Masashi, Fujii Masayuki, Togasaki Kazuhiro, Ebisudani Toshiki, Shimokawa Mariko, Takano Ai, Takahashi Sirirat, Ohta Yuki, Nanki Kosaku, Igarashi Ryo, Ishimaru Kazuhiro, Ishida Hiroki, Sukawa Yasutaka, Sugimoto Shinya, Saito Yoshimasa, Maejima Kazuhiro, Sasagawa Shota, Lee Hwajin, Kim Hong-Gee, Ha Kyungsik, Hamamoto Junko, Fukunaga Koichi, Maekawa Aya, Tanabe Minoru, Ishihara Soichiro, Hamamoto Yasuo, Yasuda Hiroyuki, Sekine Shigeki, Kudo Atsushi, Kitagawa Yuko, Kanai Takanori, Nakagawa Hidewaki, Sato Toshiro （Cell） 183 （ 5 ） 1420-1435.e21 Nov. 2020
・Research Objective: To evaluate the efficacy and safety of osimertinib in treating EGFR T790M mutation-positive non-small cell lung cancer.
- Title: Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer, Soejima Kenzo, Yasuda Hiroyuki, Hirano Toshiyuki （Expert Review of Clinical Pharmacology） 10 （ 1 ） 31-38 Jan. 2017
■Therapeutic Strategy Development
・Research Objective: To investigate the therapeutic efficacy of IL7/CCL19-expressing CAR-T cells in intractable solid tumor models of glioblastoma and pancreatic cancer.
- Title: Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer, Ohta Keisuke, Sakoda Yukimi, Adachi Keishi, Shinozaki Taro, Nakajima Masao, Yasuda Hiroyuki, Nagano Hiroaki, Tamada Koji （Cancer Research Communications） 4 （ 9 ） 2514-2524 Sep. 2024
・Research Objective: To identify the prognostic factors affecting survival in patients with advanced-stage non-small cell lung cancer treated with salvage surgery after drug therapy.
- Title: Prognostic factors affecting survival in patients with non-small cell lung cancer treated with salvage surgery after drug therapy: a multi-institutional retrospective study, Suzuki Shigeki, Asakura Keisuke, Okui Masayuki, Izawa Naoko, Sawafuji Makoto, Sakamaki Hiroyuki, Shigenobu Takao, Tajima Atsushi, Oka Naoyuki, Masai Kyohei, Kaseda Kaoru, Hishida Tomoyuki, Yasuda Hiroyuki, Fukunaga Koichi, Asamura Hisao （World Journal of Surgical Oncology） 21 （ 1 ） Sep. 2023
・Research Objective: To report a case of long-term treatment-free survival in a patient with stage IV lung adenocarcinoma after multimodal therapy.
- Title: Long-Term Treatment-Free Survival After Multimodal Therapy in a Patient with Stage IV Lung Adenocarcinoma, Takaoka Hatsuyo, Terai Hideki, Emoto Katsura, Shigematsu Lisa, Ito Fumimaro, Saito Ayaka, Okada Masahiko, Ohgino Keiko, Ikemura Shinnosuke, Yasuda Hiroyuki, Nakachi Ichiro, Kawada Ichiro, Fukunaga Koichi, Soejima Kenzo （OncoTargets and Therapy） Volume 15 981-989 Sep. 2022
■Drug Sensitivity and Resistance Analysis
・Research Objective: To assess the performance of the Oncomine Dx Target Test in detecting driver gene mutations in NSCLC patients, with a focus on its sensitivity in detecting epidermal growth factor receptor (EGFR) mutations.
- Title: Clinical utility of the Oncomine Dx Target Test multi‐CDx system and the possibility of utilizing those original sequence data, Saito Ayaka, Terai Hideki, Kim Tae‐Jung, Emoto Katsura, Kawano Ryutaro, Nakamura Kohei, Hayashi Hideyuki, Takaoka Hatsuyo, Ogata Akihiko, Kinoshita Katsuhito, Ito Fumimaro, Shigematsu Lisa, Okada Masahiko, Fukushima Takahiro, Mitsuishi Akifumi, Shinozaki Taro, Ohgino Keiko, Ikemura Shinnosuke, Yasuda Hiroyuki, Kawada Ichiro, Soejima Kenzo, Nishihara Hiroshi, Fukunaga Koichi （Cancer Medicine） 13 （ 4 ） Feb. 2024
Research Objective: To clarify whether renin-angiotensin system inhibitors can prevent pemetrexed plus platinum-induced hematological toxicities.
・Research Objective: To investigate the ability of HSP90 inhibition to overcome EGFR amplification-induced resistance to third-generation EGFR-TKIs in non-small cell lung cancer.
- Title: HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs, Watanabe Sho, Goto Yasushi, Yasuda Hiroyuki, Kohno Takashi, Motoi Noriko, Ohe Yuichiro, Nishikawa Hiroyoshi, Kobayashi Susumu S., Kuwano Kazuyoshi, Togashi Yosuke （Thoracic Cancer） 12 （ 5 ） 631-642 Mar. 2021
■Clinical Relevance Confirmation
・Research Objective: To investigate whether pre-existing interstitial lung abnormality is a potential risk factor for immune checkpoint inhibitor-related pneumonitis.
- Title: Pre-existing Interstitial Lung Abnormalities and Immune Checkpoint Inhibitor-Related Pneumonitis in Solid Tumors: A Retrospective Analysis, Horiuchi Kohei, Ikemura Shinnosuke, Sato Takashi, Shimozaki Keitaro, Okamori Satoshi, Yamada Yoshitake, Yokoyama Yoichi, Hashimoto Masahiro, Jinzaki Masahiro, Hirai Ikuko, Funakoshi Takeru, Mizuno Ryuichi, Oya Mototsugu, Hirata Kenro, Hamamoto Yasuo, Terai Hideki, Yasuda Hiroyuki, Kawada Ichiro, Soejima Kenzo, Fukunaga Koichi （The Oncologist） 29 （ 1 ） e108-e117 Jan. 2024
・Research Objective: To evaluate the relationship between exposure to osimertinib and its active metabolites and adverse events, as well as the relationship between germline polymorphisms and adverse events in Japanese patients with advanced non-small cell lung cancer.
- Title: Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study, Ishikawa Emi, Yokoyama Yuta, Chishima Haruna, Kasai Hidefumi, Kuniyoshi Ouki, Kimura Motonori, Hakamata Jun, Nakada Hideo, Suehiro Naoya, Nakaya Naoki, Nakajima Hideo, Ikemura Shinnosuke, Kawada Ichiro, Yasuda Hiroyuki, Terai Hideki, Jibiki Aya, Kawazoe Hitoshi, Soejima Kenzo, Muramatsu Hiroshi, Suzuki Sayo, Nakamura Tomonori （Investigational New Drugs） 41 （ 1 ） 122-133 Feb. 2023
・Research Objective: To evaluate the treatment of advanced non-small cell lung cancer in patients aged 80 and over in real-world clinical practice and identify suitable therapies that can improve their prognosis.
- Title: Real-world clinical practice for advanced non-small-cell lung cancer in the very elderly: A retrospective multicenter analysis, Fukushima Takahiro, Oyamada Yoshitaka, Ikemura Shinnosuke, Nukaga Shigenari, Inoue Takashi, Arai Daisuke, Ohgino Keiko, Kuroda Aoi, Ishioka Kota, Sakamaki Fumio, Suzuki Yusuke, Terai Hideki, Yasuda Hiroyuki, Kawada Ichiro, Fukunaga Koichi, Soejima Kenzo （Clinical Lung Cancer） 23 （ 6 ） 532-541 Sep. 2022
■Prognostic Factor Identification
・Research Objective: To investigate the longitudinal changes in prognostic understanding among patients with advanced lung cancer and its association with psychological distress.
- Title: Longitudinal Assessment of Prognostic Understanding in Patients with Advanced Lung Cancer and Its Association with Their Psychological Distress, Arai Daisuke, Sato Takashi, Nakachi Ichiro, Fujisawa Daisuke, Takeuchi Mari, Sato Yasunori, Kawada Ichiro, Yasuda Hiroyuki, Ikemura Shinnosuke, Terai Hideki, Nukaga Shigenari, Inoue Takashi, Nakamura Morio, Oyamada Yoshitaka, Terashima Takeshi, Sayama Koichi, Saito Fumitake, Sakamaki Fumio, Naoki Katsuhiko, Fukunaga Koichi, Soejima Kenzo （The Oncologist） 26 （ 12 ） e2265-e2273 Dec. 2021
・Research Objective: To evaluate the efficacy and safety of zoledronate-expanded autologous Vγ9Vδ2 T-cell therapy in patients with treatment-refractory non-small-cell lung cancer.
- Title: Adoptive transfer of zoledronate-expanded autologous Vγ9Vδ2 T-cells in patients with treatment-refractory non-small-cell lung cancer: a multicenter, open-label, single-arm, phase 2 study, Kakimi Kazuhiro, Matsushita Hirokazu, Masuzawa Keita, Karasaki Takahiro, Kobayashi Yukari, Nagaoka Koji, Hosoi Akihiro, Ikemura Shinnosuke, Kitano Kentaro, Kawada Ichiro, Manabe Tadashi, Takehara Tomohiro, Ebisudani Toshiaki, Nagayama Kazuhiro, Nakamura Yukio, Suzuki Ryuji, Yasuda Hiroyuki, Sato Masaaki, Soejima Kenzo, Nakajima Jun （Journal for ImmunoTherapy of Cancer） 8 （ 2 ） e001185 Sep. 2020
・Research Objective: To evaluate the efficacy and safety of induction erlotinib followed by cytotoxic chemotherapy in EGFR mutation-positive non-squamous non-small cell lung cancer patients.
- Title: A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients, Tani Tetsuo, Naoki Katsuhiko, Yasuda Hiroyuki, Arai Daisuke, Ishioka Kota, Ohgino Keiko, Yoda Satoshi, Nakayama Sohei, Satomi Ryosuke, Terai Hideki, Ikemura Shinnosuke, Sato Takashi, Soejima Kenzo （Cancer Chemotherapy and Pharmacology） 84 （ 5 ） 1065-1071 Nov. 2019
■Biological and Molecular Characterization
・Research Objective: To investigate the effect of blocking the FGF/FGFR pathway on lung adenocarcinoma and its associated cancer-associated fibroblasts.
- Title: Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer‐associated fibroblasts, Hegab Ahmed E, Ozaki Mari, Kameyama Naofumi, Gao Jingtao, Kagawa Shizuko, Yasuda Hiroyuki, Soejima Kenzo, Yin Yongjun, Guzy Robert D, Nakamura Yoshikazu, Ornitz David M, Betsuyaku Tomoko （The Journal of Pathology） 249 （ 2 ） 193-205 Oct. 2019
・Research Objective: To evaluate the efficacy of afatinib or osimertinib plus cetuximab combination therapy in experimental NSCLC models with EGFR exon 20 insertion mutations.
- Title: Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations, Hasegawa Hanako, Yasuda Hiroyuki, Hamamoto Junko, Masuzawa Keita, Tani Tetsuo, Nukaga Shigenari, Hirano Toshiyuki, Kobayashi Keigo, Manabe Tadashi, Terai Hideki, Ikemura Shinnosuke, Kawada Ichiro, Naoki Katsuhiko, Soejima Kenzo （Lung Cancer） 127 146-152 Jan. 2019
・Research Objective: To characterize the efficacy and mechanism of activation and resistance of naquotinib, a novel third-generation EGFR tyrosine kinase inhibitor, in EGFR-mutated non-small cell lung cancer.
- Title: Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non–Small Cell Lung Cancer, Hirano Toshiyuki, Yasuda Hiroyuki, Hamamoto Junko, Nukaga Shigenari, Masuzawa Keita, Kawada Ichiro, Naoki Katsuhiko, Niimi Tatsuya, Mimasu Shinya, Sakagami Hideki, Soejima Kenzo, Betsuyaku Tomoko （Molecular Cancer Therapeutics） 17 （ 4 ） 740-750 Apr. 2018
■Biomarker Evaluation
・Research Objective: To investigate the correlation between intracellular levels of reactive oxygen species and sensitivity to ABT-263 in non-small-cell lung cancer cells.
- Title: Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells, Ohgino Keiko, Terai Hideki, Yasuda Hiroyuki, Nukaga Shigenari, Hamamoto Junko, Tani Tetsuo, Kuroda Aoi, Arai Daisuke, Ishioka Kota, Masuzawa Keita, Ikemura Shinnosuke, Kawada Ichiro, Naoki Katsuhiko, Fukunaga Koichi, Soejima Kenzo （Cancer Science） 111 （ 10 ） 3793-3801 Oct. 2020
・Research Objective: To evaluate the sensitivity, specificity, and parallelism of EGFR T790M mutation detection using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer.
- Title: Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer, Kobayashi Keigo, Naoki Katsuhiko, Manabe Tadashi, Masuzawa Keita, Hasegawa Hanako, Yasuda Hiroyuki, Kawada Ichiro, Soejima Kenzo, Betsuyaku Tomoko （OncoTargets and Therapy） Volume 11 3335-3343 Jun. 2018
・Research Objective: To examine the ability of CD44v, either alone or in combination with ALDH, to identify cancer stem cells within human lung cancer cell lines.
- Title: Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma, Nishino Makoto, Ozaki Mari, Hegab Ahmed E., Hamamoto Junko, Kagawa Shizuko, Arai Daisuke, Yasuda Hiroyuki, Naoki Katsuhiko, Soejima Kenzo, Saya Hideyuki, Betsuyaku Tomoko （Journal of Cancer） 8 （ 10 ） 1774-1785
■Clinical Safety Assessment
・Research Objective: To evaluate the efficacy of osimertinib for EGFR exon 20 insertion-positive non-small cell lung cancer in a prospective clinical trial.
- Title: A phase I/II study of osimertinib in EGFR exon 20 insertion mutation-positive non-small cell lung cancer, Yasuda Hiroyuki, Ichihara Eiki, Sakakibara-Konishi Jun, Zenke Yoshitaka, Takeuchi Shinji, Morise Masahiro, Hotta Katsuyuki, Sato Mineyoshi, Matsumoto Shingo, Tanimoto Azusa, Matsuzawa Reiko, Kiura Katuyuki, Takashima Yuta, Yano Seiji, Koyama Junji, Fukushima Takahiro, Hamamoto Junko, Terai Hideki, Ikemura Shinnosuke, Takemura Ryo, Goto Koichi, Soejima Kenzo （Lung Cancer） 162 140-146 Dec. 2021
・Research Objective: To report a unique case of severe erythema multiforme-like eruption and interstitial pneumonia occurring sequentially after nivolumab therapy, highlighting the need for dermatologists to monitor unexpected adverse events in melanoma treatment.
- Title: Unexpected recalcitrant course of drug‐induced erythema multiforme‐like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy, Nomura Hisashi, Takahashi Hayato, Suzuki Satsuki, Kurihara Yuichi, Chubachi Shotaro, Kawada Ichiro, Yasuda Hiroyuki, Betsuyaku Tomoko, Amagai Masayuki, Funakoshi Takeru （The Journal of Dermatology） 44 （ 7 ） 818-821 Jul. 2017
・Research Objective: To document and analyze the phenomenon of accelerated disease progression after the discontinuation of nintedanib therapy in patients with idiopathic pulmonary fibrosis.
- Title: Suspected accelerated disease progression after discontinuation of nintedanib in patients with idiopathic pulmonary fibrosis, Okamori Satoshi, Asakura Takanori, Masuzawa Keita, Yasuda Hiroyuki, Kamata Hirofumi, Ishii Makoto, Betsuyaku Tomoko （Medicine） 96 （ 49 ） e9081 Dec. 2017
■Pharmacokinetic Profile Establishment
・Research Objective: To evaluate the efficacy, safety, and pharmacokinetics of biapenem administered thrice daily in elderly patients with pneumonia.
- Title: The efficacy, safety, and pharmacokinetics of biapenem administered thrice daily for the treatment of pneumonia in the elderly, Namkoong Ho, Kameyama Youjyu, Yasuda Hiroyuki, Nakayama Sohei, Kaneko Hiroshi, Kawashima Chieko, Terajima Tomoko, Maezawa Kayoko, Hayashi Takeshi, Sandoh Mitsuru, Ishii Makoto, Tasaka Sadatomo, Kanayama Akiko, Kobayashi Intetsu, Betsuyaku Tomoko, Kizu Junko, Iwata Satoshi, Sato Yoshitake, Hasegawa Naoki （Journal of Infection and Chemotherapy） 20 （ 6 ） 356-360 Jun. 2014
■Therapeutic Target Discovery
・Research Objective: To identify and evaluate SHOC2 as a modulator of sensitivity to EGFR-TKIs in non-small cell lung cancer cells.
- Title: SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells, Terai Hideki, Hamamoto Junko, Emoto Katsura, Masuda Takeshi, Manabe Tadashi, Kuronuma Satoshi, Kobayashi Keigo, Masuzawa Keita, Ikemura Shinnosuke, Nakayama Sohei, Kawada Ichiro, Suzuki Yusuke, Takeuchi Osamu, Suzuki Yukio, Ohtsuki Sumio, Yasuda Hiroyuki, Soejima Kenzo, Fukunaga Koichi （Molecular Cancer Research） 19 （ 2 ） 317-328 Feb. 2021
・Research Objective: To identify FOXD1 expression as a prognostic marker and potential therapeutic target in non-small cell lung cancer.
- Title: Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer, Ohgino Keiko, Soejima Kenzo, Yasuda Hiroyuki, Hayashi Yuichiro, Hamamoto Junko, Naoki Katsuhiko, Arai Daisuke, Ishioka Kota, Sato Takashi, Terai Hideki, Ikemura Shinnosuke, Yoda Satoshi, Tani Tetsuo, Kuroda Aoi, Betsuyaku Tomoko （Lung Cancer） 83 （ 1 ） 90-96 Jan. 2014
■Assay Development
・Research Objective: Establishment of an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2 infection modeling and drug screening.
- Title: Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening, Ebisudani Toshiki, Sugimoto Shinya, Haga Kei, Mitsuishi Akifumi, Takai-Todaka Reiko, Fujii Masayuki, Toshimitsu Kohta, Hamamoto Junko, Sugihara Kai, Hishida Tomoyuki, Asamura Hisao, Fukunaga Koichi, Yasuda Hiroyuki, Katayama Kazuhiko, Sato Toshiro （Cell Reports） 35 （ 10 ） 109218 Jun. 2021
・Research Objective: To establish an in vitro assay to study lung and trachea stem cells and characterize the effectors of their behavior.
- Title: Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior, Hegab Ahmed E., Arai Daisuke, Gao Jingtao, Kuroda Aoi, Yasuda Hiroyuki, Ishii Makoto, Naoki Katsuhiko, Soejima Kenzo, Betsuyaku Tomoko （Stem Cell Research） 15 （ 1 ） 109-121 Jul. 2015
■Case Report of Adverse Reaction
・Research Objective: Investigation of secondary brain neoplasm occurrence after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer.
- Title: Secondary Brain Neoplasm after Stereotactic Radiosurgery in Patients with Metastatic Non-small Cell Lung Cancer, Nukaga Shigenari, Naoki Katsuhiko, Yasuda Hiroyuki, Kawada Ichiro, Ohara Kentaro, Soejima Kenzo, Betsuyaku Tomoko （Internal Medicine） 57 （ 16 ） 2383-2387 Aug. 2018
・Research Objective: To evaluate the effectiveness of alectinib as a treatment option for patients with crizotinib-induced interstitial lung disease in ALK-positive advanced non-small-cell lung cancer.
- Title: Alectinib as a treatment option following recovery from crizotinib-induced interstitial lung disease in patients with anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer, NUKAGA SHIGENARI, NAOKI KATSUHIKO, KAMO TETSURO, MASUZAWA KEITA, YASUDA HIROYUKI, SOEJIMA KENZO, BETSUYAKU TOMOKO （Molecular and Clinical Oncology） 4 （ 6 ） 1085-1087 Jun. 2016
・Research Objective: To demonstrate the effectiveness of combination treatment with afatinib and a glucocorticoid for lung cancer patients who develop EGFR-TKI-induced interstitial lung disease.
- Title: Successful treatment of non-small-cell lung cancer with afatinib and a glucocorticoid following gefitinib- and erlotinib-induced interstitial lung disease: A case report, Tani Tetsuo, Naoki Katsuhiko, Asakura Takanori, Hirano Toshiyuki, Suzuki Shoji, Masuzawa Keita, Hasegawa Hanako, Kuroda Aoi, Yasuda Hiroyuki, Ishii Makoto, Soejima Kenzo, Betsuyaku Tomoko （Molecular and Clinical Oncology） 5 （ 4 ） 488-490 Oct. 2016
■Quality of Life Impact Assessment
・Research Objective: To determine what patients with advanced lung cancer value most after diagnosis and identify any associated factors.
- Title: Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer, Kameyama Naofumi, Sato Takashi, Arai Daisuke, Fujisawa Daisuke, Takeuchi Mari, Nakachi Ichiro, Kawada Ichiro, Yasuda Hiroyuki, Ikemura Shinnosuke, Terai Hideki, Nukaga Shigenari, Nakano Yasushi, Hirano Toshiyuki, Minematsu Naoto, Asakura Takanori, Kamatani Takashi, Tanaka Kyuto, Suzuki Shoji, Miyawaki Masayoshi, Naoki Katsuhiko, Fukunaga Koichi, Soejima Kenzo （JCO Oncology Practice） 18 （ 12 ） e1977-e1986 Dec. 2022
・Research Objective: To conduct a comprehensive and nationwide survey assessing the sequelae of COVID-19 in Japan, evaluating health-related quality of life, socioeconomic status, and risk factors in 1000 patients.
- Title: Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol, Nakagawara Kensuke, Namkoong Ho, Terai Hideki, Masaki Katsunori, Tanosaki Takae, Shimamoto Kyoko, Lee Ho, Tanaka Hiromu, Okamori Satoshi, Kabata Hiroki, Chubachi Shotaro, Ikemura Shinnosuke, Kamata Hirofumi, Yasuda Hiroyuki, Kawada Ichiro, Ishii Makoto, Ishibashi Yoshiki, Harada Sei, Fujita Takanori, Ito Daisuke, Bun Shogyoku, Tabuchi Hajime, Kanzaki Sho, Shimizu Eisuke, Fukuda Keitaro, Yamagami Jun, Kobayashi Keigo, Hirano Toshiyuki, Inoue Takashi, Kagyo Junko, Shiomi Tetsuya, Ohgino Keiko, Sayama Koichi, Otsuka Kengo, Miyao Naoki, Odani Toshio, Oyamada Yoshitaka, Masuzawa Keita, Nakayama Sohei, Suzuki Yusuke, Baba Rie, Nakachi Ichiro, Kuwahara Naota, Ishiguro Takashi, Mashimo Shuko, Minematsu Naoto, Ueda Soichiro, Manabe Tadashi, Funatsu Yohei, Koh Hidefumi, Yoshiyama Takashi, Saito Fumitake, Ishioka Kota, Takahashi Saeko, Nakamura Morio, Goto Ai, Harada Norihiro, Kusaka Yu, Nakano Yasushi, Nishio Kazumi, Tateno Hiroki, Edahiro Ryuya, Takeda Yoshito, Kumanogoh Atsushi, Kodama Nobuhiro, Okamoto Masaki, Umeda Akira, Hagimura Kazuto, Sato Toshiro, Miyazaki Naoki, Takemura Ryo, Sato Yasunori, Takebayashi Toru, Nakahara Jin, Mimura Masaru, Ogawa Kaoru, Shimmura Shigeto, Negishi Kazuno, Tsubota Kazuo, Amagai Masayuki, Goto Rei, Ibuka Yoko, Hasegawa Naoki, Kitagawa Yuko, Kanai Takanori, Fukunaga Koichi （BMJ Open Respiratory Research） 8 （ 1 ） e001015 Nov. 2021
・Research Objective: To investigate whether targeted therapy-induced facial skin toxicities affect quality of life and identify factors related to quality of life in patients with advanced/recurrent cancer.
- Title: Targeted Therapy-induced Facial Skin Toxicities: Impact on Quality of Life in Cancer Patients, Yagasaki Kaori, Komatsu Hiroko, Soejima Kenzo, Naoki Katsuhiko, Kawada Ichiro, Yasuda Hiroyuki, Hamamoto Yasuo （Asia-Pacific Journal of Oncology Nursing） 5 （ 2 ） 172-177 Apr. 2018
■New Research Methodology Development
・Research Objective: To develop a molecular dynamics simulation-based model to predict the sensitivity of rare EGFR mutants to EGFR-TKIs in nonsmall cell lung carcinoma.
- Title: Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations, Ikemura Shinnosuke, Yasuda Hiroyuki, Matsumoto Shingo, Kamada Mayumi, Hamamoto Junko, Masuzawa Keita, Kobayashi Keigo, Manabe Tadashi, Arai Daisuke, Nakachi Ichiro, Kawada Ichiro, Ishioka Kota, Nakamura Morio, Namkoong Ho, Naoki Katsuhiko, Ono Fumie, Araki Mitsugu, Kanada Ryo, Ma Biao, Hayashi Yuichiro, Mimaki Sachiyo, Yoh Kiyotaka, Kobayashi Susumu S., Kohno Takashi, Okuno Yasushi, Goto Koichi, Tsuchihara Katsuya, Soejima Kenzo （Proceedings of the National Academy of Sciences） 116 （ 20 ） 10025-10030 May. 2019
- URL: https://doi.org/10.1073/pnas.1819430116 Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations ・Research Objective: To describe the successful management of transient asymptomatic pulmonary opacities in a patient with EGFR-mutant non-small cell lung cancer using a 'stop-and-go' approach with osimertinib.
- Title: EGFR-mutant Non-small Cell Lung Cancer Accompanied by Transient Asymptomatic Pulmonary Opacities Successfully Treated with "Stop-And-Go" Osimertinib, Kobayashi Keigo, Naoki Katsuhiko, Kuroda Aoi, Yasuda Hiroyuki, Kawada Ichiro, Soejima Kenzo, Betsuyaku Tomoko （Internal Medicine） 57 （ 7 ） 1007-1010
・Research Objective: To investigate whether variations in cigarette smoke exposure patterns affect tumorigenesis and the development of emphysema.
- Title: Intermittent Exposure to Cigarette Smoke Increases Lung Tumors and the Severity of Emphysema More than Continuous Exposure, Kameyama Naofumi, Chubachi Shotaro, Hegab Ahmed E., Yasuda Hiroyuki, Kagawa Shizuko, Tsutsumi Akihiro, Fukunaga Koichi, Shimoda Masayuki, Kanai Yae, Soejima Kenzo, Betsuyaku Tomoko （American Journal of Respiratory Cell and Molecular Biology） 59 （ 2 ） 179-188 Aug. 2018
■Patient and Caregiver Concerns Study
・Research Objective: To investigate concerns in both patients with advanced lung cancer and their family caregivers longitudinally from diagnosis.
- Title: Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study, Sato Takashi, Fujisawa Daisuke, Arai Daisuke, Nakachi Ichiro, Takeuchi Mari, Nukaga Shigenari, Kobayashi Keigo, Ikemura Shinnosuke, Terai Hideki, Yasuda Hiroyuki, Kawada Ichiro, Sato Yasunori, Satomi Ryosuke, Takahashi Saeko, Hashiguchi Mizuha Haraguchi, Nakamura Morio, Oyamada Yoshitaka, Terashima Takeshi, Sayama Koichi, Saito Fumitake, Sakamaki Fumio, Inoue Takashi, Naoki Katsuhiko, Fukunaga Koichi, Soejima Kenzo （Palliative Medicine） 35 （ 5 ） 943-951 May. 2021
■Risk Factor Identification for Disease Sequelae
・Research Objective: To investigate the distribution of long COVID in Japanese patients through a nationwide prospective cohort study.
- Title: Comprehensive Analysis of Long COVID in a Japanese Nationwide Prospective Cohort Study, Terai Hideki, Ishii Makoto, Takemura Ryo, Namkoong Ho, Shimamoto Kyoko, Masaki Katsunori, Tanosaki Takae, Chubachi Shotaro, Matsuyama Emiko, Hayashi Reina, Shimada Takashi, Shigematsu Lisa, Ito Fumimaro, Kaji Masanori, Takaoka Hatsuyo, Kurihara Momoko, Nakagawara Kensuke, Tomiyasu Saki, Sasahara Kotaro, Saito Ayaka, Otake Shiro, Azegawa Shuhei, Okada Masahiko, Fukushima Takahiro, Morita Atsuho, Tanaka Hiromu, Sunata Keeya, Asaoka Masato, Nishie Miyuki, Shinozaki Taro, Ebisudani Toshiki, Akiyama Yuto, Mitsuishi Akifumi, Nakayama Shingo, Ogawa Takunori, Sakurai Kaori, Kuwae Misato, Yagi Kazuma, Ohgino Keiko, Miyata Jun, Kabata Hiroki, Ikemura Shinnosuke, Kamata Hirofumi, Yasuda Hiroyuki, Kawada Ichiro, Kimura Ryusei, Kondo Masahiro, Iwasaki Toshiki, Ishida Noriyuki, Hiruma Gaku, Miyazaki Naoki, Ishibashi Yoshiki, Harada Sei, Fujita Takanori, Ito Daisuke, Bun Shogyoku, Tabuchi Hajime, Kanzaki Sho, Shimizu Eisuke, Fukuda Keitaro, Yamagami Jun, Kobayashi Keigo, Hirano Toshiyuki, Inoue Takashi, Hashiguchi Mizuha, Kagyo Junko, Shiomi Tetsuya, Lee Ho, Sugihara Kai, Omori Nao, Sayama Koichi, Otsuka Kengo, Miyao Naoki, Odani Toshio, Mochimaru Takao, Satomi Ryosuke, Oyamada Yoshitaka, Masuzawa Keita, Asakura Takanori, Watase Mayuko, Nakayama Sohei, Suzuki Yusuke, Baba Rie, Okamori Satoshi, Arai Daisuke, Nakachi Ichiro, Kuwahara Naota, Fujiwara Akiko, Okada Takenori, Ishiguro Takashi, Isono Taisuke, Makino Yasushi, Mashimo Shuko, Kaido Tatsuya, Minematsu Naoto, Ueda Soichiro, Minami Kazuhiro, Hagiwara Rie, Manabe Tadashi, Fukui Takahiro, Funatsu Yohei, Koh Hidefumi, Yoshiyama Takashi, Kokuto Hiroyuki, Kusumoto Tatsuya, Oashi Ayano, Miyawaki Masayoshi, Saito Fumitake, Tani Tetsuo, Ishioka Kota, Takahashi Saeko, Nakamura Morio, Harada Norihiro, Sasano Hitoshi, Nakamura Ai, Kusaka Yu, Ohba Takehiko, Nakano Yasushi, Nishio Kazumi, Nakajima Yukiko, Suzuki Shoji, Yoshida Shuichi, Tateno Hiroki, Kodama Nobuhiro, Maeda Shunsuke, Sakamoto Satoshi, Okamoto Masaki, Nagasaki Yoji, Umeda Akira, Miyagawa Kasuya, Shimada Naoto, Hagimura Kazuto, Nagashima Kengo, Sato Toshiro, Sato Yasunori, Hasegawa Naoki, Takebayashi Toru, Nakahara Jin, Mimura Masaru, Ogawa Kaoru, Shimmura Shigeto, Negishi Kazuno, Tsubota Kazuo, Amagai Masayuki, Goto Rei, Ibuka Yoko, Kitagawa Yuko, Kanai Takanori, Fukunaga Koichi （SSRN Electronic Journal）
■New Category: Text Analysis and Processing
・Research Objective: Investigation of the underlying causes and appropriate treatment for long-term nonresolving pneumonia in a 70-year-old woman.
- Title: A 70-Year-Old Woman With Long-Term Nonresolving Pneumonia, Tomiyasu Saki, Kabata Hiroki, Emoto Katsura, Azekawa Shuhei, Maeda Chihaya, Masai Kyohei, Yasuda Hiroyuki, Fukunaga Koichi （Chest） 161 （ 4 ） e219-e223 Apr. 2022

Areas of Research

・Molecular Biology
・Cell Biology
・Pulmonology

Social Contributions

・Enhancement of targeted cancer therapies through understanding lung cancer biology.
・Development of a translational research system for refractory or rare lung cancers, improving patient prognosis.
・Improvement of cancer treatment through visualization of drug effects and personalized therapy development.