0

Introduction

My specialty is molecular biology. I aim to create new biotechnology centered around proteins and utilize this original technology to aid in the understanding and control of life. My current themes include the creation of new proteins and peptides useful in the fields of biopharmaceuticals and drug delivery systems (DDS), as well as in the fields of environment and energy, the experimental proof of the origin and evolution of life, and the development of proteome analysis technology.

Achievements

■Drug Delivery Systems
・Research Objective: Provision of intracellular delivery systems for biopharmaceuticals consisting of biopolymers such as antibodies, peptides, and nucleic acids, utilizing original membrane penetration-enhancing peptides
- Title: Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide, Nakamura Momoko, Fujiwara Kei, Doi Nobuhide (Journal of Nanobiotechnology) 20 458 Oct. 2022
- Title: Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication, Ide Mayuko, Tabata Noriko, Yonemura Yuko, Shirasaki Takayoshi, Murai Kazuhisa, Wang Ying, Ishida Atsuya, Okada Hikari, Honda Masao, Kaneko Shuichi, Doi Nobuhide, Ito Satoru, Yanagawa Hiroshi (Journal of Biological Chemistry) 298 102097 Jul. 2022
- Title: Human-derived fusogenic peptides for the intracellular delivery of proteins, Sudo Kei, Niikura Keisuke, Iwaki Kouta, Kohyama Shunshi, Fujiwara Kei, Doi Nobuhide (Journal of Controlled Release) 255 1-11 Jun. 2017
■Antibody and Peptide Development
・Research Objective: Creating antibodies and peptides that bind to desired target molecules such as disease targets and cell selection markers using original protein evolutionary engineering technologies based on cell-free protein synthesis systems
- Title: PURE mRNA display for in vitro selection of single-chain antibodies, Nagumo Yu, Fujiwara Kei, Horisawa Kenichi, Yanagawa Hiroshi, Doi Nobuhide (Journal of Biochemistry) 159 519-26 May 2016
- Title: mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction, Shiheido Hirokazu, Takashima Hideaki, Doi Nobuhide, Yanagawa Hiroshi (PLoS One) 6 e17898 Mar. 2011
- Title: Bicistronic DNA display for in vitro selection of Fab fragments, Sumida Takeshi, Doi Nobuhide, Yanagawa Hiroshi (Nucleic Acids Research) 37 e147 Dec. 2009

Areas of Research

・Biofunctional Application, Bioprocess Engineering
・Biomedical Engineering
・Systems Genomics
・Applied Molecular and Cellular Biology
・Evolutionary Biology
・Biophysics
・Molecular Biology
・Biomaterials Science

Social Contributions

・Advancing Drug Delivery Systems
・Developing Next-Generation Antibody Drugs
Video

The corresponding video could not be found.