- Researchmap Member ID
- 1000182370
- Keio Researchers Information System (K-RIS)
- Researcher Details - Suenaga, Kiyotake
- Lab/Seminar URL
- http://user.keio.ac.jp/~suenaga/
Introduction
- The discovery of new bioactive substances can bring groundbreaking advancements to various scientific fields. Our group isolates such bioactive substances from nature and elucidates their structures. Furthermore, we conduct bioorganic chemical research aimed at the chemical synthesis and elucidation of the mechanisms of action of these bioactive natural products.
Achievements
- ■Marine Biotechnology
・Research Objective: To evaluate the toxicity of polycavernoside E and akunolides A, B, and C from the marine cyanobacterium Okeania sp. in mice.
- Title: Toxicity of the marine glycosidic macrolides, polycavernoside E and akunolides, from Okinawan cyanobacterium Okeania sp. in mice, Yotsu-Yamashita Mari, Umeda Kairi, Iwasaki Arihiro, Suenaga Kiyotake （Toxicon） 250 108122 Nov. 2024
・Research Objective: To understand the biosynthetic mechanisms and unique enzymatic processes involved in the production of lyngbyapeptin B by the marine cyanobacterium Moorena bouillonii.
- Title: Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii, Kudo Fumitaka, Chikuma Takuji, Nambu Mizuki, Chisuga Taichi, Sumimoto Shimpei, Iwasaki Arihiro, Suenaga Kiyotake, Miyanaga Akimasa, Eguchi Tadashi （ACS Chemical Biology） 18 （ 4 ） 875-883 Apr. 2023
・Research Objective: To explore the potential of marine natural products as sources of novel anticancer drugs.
- Title: Marine Natural Products: A Source of Novel Anticancer Drugs, Khalifa Shaden A. M., Elias Nizar, Farag Mohamed A., Chen Lei, Saeed Aamer, Hegazy Mohamed-Elamir F., Moustafa Moustafa S., Abd El-Wahed Aida, Al-Mousawi Saleh M., Musharraf Syed G., Chang Fang-Rong, Iwasaki Arihiro, Suenaga Kiyotake, Alajlani Muaaz, Göransson Ulf, El-Seedi Hesham R. （Marine Drugs） 17 （ 9 ） 491 Aug. 2019
■Mechanism of Action
・Research Objective: To demonstrate that methionine aminopeptidase 2 (EhMetAP2) is the primary target for the amebicidal activity of fumagillin against Entamoeba histolytica.
- Title: Fumagillin inhibits growth of the enteric protozoan parasite
Entamoeba histolytica
by covalently binding to and selectively inhibiting methionine aminopeptidase 2, Watanabe Natsuki, Saito-Nakano Yumiko, Kurisawa Naoaki, Otomo Keisuke, Suenaga Kiyotake, Nakano Kentaro, Nozaki Tomoyoshi （Antimicrobial Agents and Chemotherapy） 67 （ 11 ） Nov. 2023
- URL: Fumagillin inhibits growth of the enteric protozoan parasite
Entamoeba histolytica
by covalently binding to and selectively inhibiting methionine aminopeptidase 2
・Research Objective: The objective is to determine the structure, perform total synthesis, and evaluate the biological activity of iezoside, a potent Ca2+-ATPase inhibitor from the marine cyanobacterium Leptochromothrix valpauliae.
- Title: Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca2+-ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae, Kurisawa Naoaki, Iwasaki Arihiro, Teranuma Kazuya, Dan Shingo, Toyoshima Chikashi, Hashimoto Masaru, Suenaga Kiyotake （Journal of the American Chemical Society） 144 （ 24 ） 11019-11032 Jun. 2022
・Research Objective: Isolation and structural determination of new pyrrolinone-containing lipopeptides from an Okeania sp. marine cyanobacterium and evaluation of their biological activity in stimulating glucose uptake.
- Title: Ypaoamides B and C, Linear Lipopeptides from an Okeania sp. Marine Cyanobacterium, Sueyoshi Kosuke, Yamada Miki, Yamano Aki, Ozaki Kaori, Sumimoto Shimpei, Iwasaki Arihiro, Suenaga Kiyotake, Teruya Toshiaki （Journal of Natural Products） 81 （ 4 ） 1103-1107 Apr. 2018
■Drug Discovery
・Research Objective: To establish a total synthesis method for ikoamide to facilitate its biological evaluation and the development of novel analogues.
- Title: Total Synthesis of Ikoamide, a Highly N-Methylated Antimalarial Lipopeptide, Lo Yung-Han, Iwasaki Arihiro, Suenaga Kiyotake （The Journal of Organic Chemistry） 88 （ 15 ） 10565-10573 Aug. 2023
・Research Objective: To investigate the secondary metabolites of marine cyanobacteria and discover novel bioactive compounds.
- Title: Bioorganic Study of New Natural Products Isolated from Marine Cyanobacteria, Iwasaki Arihiro, Suenaga Kiyotake （Journal of Synthetic Organic Chemistry, Japan） 79 （ 2 ） 133-144 Feb. 2021
・Research Objective: To characterize the metabolomic profile of a cf. Neolyngbya cyanobacterium from the South China Sea and identify wenchangamide A, a lipopeptide with apoptotic potential in colon cancer cells.
- Title: Metabolomic Characterization of a cf. Neolyngbya Cyanobacterium from the South China Sea Reveals Wenchangamide A, a Lipopeptide with In Vitro Apoptotic Potential in Colon Cancer Cells, Ding Lijian, Bar-Shalom Rinat, Aharonovich Dikla, Kurisawa Naoaki, Patial Gaurav, Li Shuang, He Shan, Yan Xiaojun, Iwasaki Arihiro, Suenaga Kiyotake, Zhu Chengcong, Luo Haixi, Tian Fuli, Fares Fuad, Naman C. Benjamin, Luzzatto-Knaan Tal （Marine Drugs） 19 （ 7 ） 397 Jul. 2021
■Genomics
・Research Objective: To investigate the genetic diversity of filamentous cyanobacteria from shore regions of Okinawa and their potential as resources for drug discovery.
- Title: Bioactive Substances from Marine Cyanobacteria, Suenaga Kiyotake, Iwasaki Arihiro （Topics in Heterocyclic Chemistry） 277-295
■Synthesis Methodology
・Research Objective: To investigate the structure-activity relationship of iezoside and its analogs as potent Ca2+ ATPase inhibitors.
- Title: Structure–activity relationship studies on iezoside, a highly potent Ca2+ ATPase inhibitor, Kurisawa Naoaki, Teranuma Kazuya, Noto Akari, Iwasaki Arihiro, Kabashima Yoshiki, Nakajima Rie, Toyoshima Chikashi, Suenaga Kiyotake （Bulletin of the Chemical Society of Japan） 97 （ 7 ） Jul. 2024
・Research Objective: To achieve the first total synthesis of caldorazole using a convergent synthetic route.
- Title: Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers, Miyamoto Yuta, Iwasaki Arihiro, Fujimura Haruka, Kudo Chihiro, Kurisawa Naoaki, Ohno Osamu, Suenaga Kiyotake （The Journal of Organic Chemistry） 88 （ 5 ） 3208-3216 Mar. 2023
・Research Objective: The objective of this research is the total synthesis of acetylene-containing lipopeptides odookeanynes A and B and the evaluation of their antitrypanosomal activity.
- Title: Total synthesis of acetylene-containing lipopeptides odookeanynes A and B, Lo Yung-Han, Umeda Kairi, Kurisawa Naoaki, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake （Tetrahedron Letters） 130 154763 Oct. 2023
■Allelopathy Research
・Research Objective: To explore the allelopathic potential of Oldenlandia corymbosa for weed control purposes.
- Title: Allelopathic potential of
Oldenlandia corymbosa
and identification of its allelopathic substances, Kyaw Ei Han, Hossen Kawsar, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi （Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology） 158 （ 3 ） 394-403 May. 2024
- URL: Allelopathic potential of
Oldenlandia corymbosa
and identification of its allelopathic substances
・Research Objective: To investigate the allelopathic activity and allelochemicals of Chamaecyparis obtusa leaves for developing sustainable agriculture applications.
- Title: Allelopathy and Allelochemicals in Chamaecyparis obtusa Leaves for the Development of Sustainable Agriculture, Kato-Noguchi Hisashi, Mori Kumpei, Iwasaki Arihiro, Suenaga Kiyotake （Agronomy） 14 （ 7 ） 1557 Jul. 2024
・Research Objective: Investigation of the allelopathic activity of Liriodendron tulipifera leaf waste for sustainable weed management.
- Title: Allelopathic Activity of Leaf Wastes of Liriodendron tulipifera for Sustainable Management, Kato-Noguchi Hisashi, Hayashi Kota, Iwasaki Arihiro, Suenaga Kiyotake （Applied Sciences） 14 （ 18 ） 8437 Sep. 2024
■Biodiversity Assessment
・Research Objective: Characterization of macroscopic colony-forming filamentous cyanobacteria from Okinawan coasts to assess their diversity and potential as sources of bioactive compounds.
- Title: Characterization of Macroscopic Colony-Forming Filamentous Cyanobacteria from Okinawan Coasts as Potential Sources of Bioactive Compounds, Nuryadi Handung, Sumimoto Shimpei, Teruya Toshiaki, Suenaga Kiyotake, Suda Shoichiro （Marine Biotechnology） 22 （ 6 ） 824-835 Dec. 2020
■Environmental Management
・Research Objective: To investigate the phytotoxic activity of burdock and its active substances for potential use in weed management.
- Title: Phytotoxic activity of crop residues from Burdock and an active substance, Suzuki Masahiko, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi （Journal of Environmental Science and Health, Part B） 54 （ 11 ） 877-882 Nov. 2019
・Research Objective: To investigate the allelopathic effects of loliolide from water hyacinth on the growth of various terrestrial plant species.
- Title: Growth limiting effects on various terrestrial plant species by an allelopathic substance, loliolide, from water hyacinth, Kato-Noguchi Hisashi, Moriyasu Mayumi, Ohno Osamu, Suenaga Kiyotake （Aquatic Botany） 117 56-61 Jul. 2014
■Toxicology
・Research Objective: Isolation and characterization of wajeepeptin, a cytotoxic and antitrypanosomal cyclic depsipeptide from a marine Moorena sp. cyanobacterium.
- Title: Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine Moorena sp. Cyanobacterium, Kurisawa Naoaki, Jeelani Ghulam, Nozaki Tomoyoshi, Agusta Adnan Luthfi, Suenaga Kiyotake, Iwasaki Arihiro （Journal of Natural Products） 87 （ 7 ） 1838-1843 Jul. 2024
・Research Objective: Isolation and structure determination of new macrolide glycosides from a marine Okeania sp. cyanobacterium.
- Title: Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine Okeania sp. Cyanobacterium, Umeda Kairi, Iwasaki Arihiro, Taguchi Raimu, Kurisawa Naoaki, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake （Journal of Natural Products） 86 （ 11 ） 2529-2538 Nov. 2023
・Research Objective: To isolate and characterize Caldorazole, a thiazole-containing polyketide with selective cytotoxicity under glucose-restricted conditions.
- Title: Isolation of Caldorazole, a Thiazole-Containing Polyketide with Selective Cytotoxicity under Glucose-Restricted Conditions, Ohno Osamu, Iwasaki Arihiro, Same Kyouhei, Kudo Chihiro, Aida Erika, Sugiura Kazuya, Sumimoto Shimpei, Teruya Toshiaki, Tashiro Etsu, Simizu Siro, Matsuno Kenji, Imoto Masaya, Suenaga Kiyotake （Organic Letters） 24 （ 25 ） 4547-4551 Jul. 2022
■Stereochemistry / 立体化学
・Research Objective: To isolate and characterize the apoptosis-inducing lipopeptide jahanyne from the marine cyanobacterium Lyngbya sp.
- Title: ChemInform Abstract: Jahanyne, an Apoptosis‐Inducing Lipopeptide from the Marine Cyanobacterium Lyngbya sp., Iwasaki Arihiro, Ohno Osamu, Sumimoto Shinpei, Ogawa Hidetoshi, Nguyen Kim Anh, Suenaga Kiyotake （ChemInform） 46 （ 26 ） Jun. 2015
■Structural Elucidation
・Research Objective: Isolation and structure determination of a new analog of polycavernosides from marine Okeania sp. cyanobacterium.
- Title: Isolation and structure determination of a new analog of polycavernosides from marine Okeania sp. cyanobacterium, Umeda Kairi, Kurisawa Naoaki, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake, Iwasaki Arihiro （Beilstein Journal of Organic Chemistry） 20 645-652 Mar. 2024
・Research Objective: To investigate the differentiation-promoting effects of okeaniamides A and B from an Okeania sp. marine cyanobacterium on mouse 3T3-L1 preadipocytes.
- Title: Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes, Ozaki Kaori, Asato Yuka, Natsume Noriyuki, Tojo Shunya, Sumimoto Shimpei, Iwasaki Arihiro, Suenaga Kiyotake, Teruya Toshiaki （Journal of Natural Products） 86 （ 6 ） 1564-1570 Jun. 2023
・Research Objective: Isolation and total synthesis of new natural products, hennaminal and hennamide, from the marine cyanobacterium Rivularia sp., and investigation of their antitrypanosomal activities.
- Title: Isolation of Hennaminal and Isolation and Total Synthesis of Hennamide, Pyrrolinone Compounds from the Marine Cyanobacterium Rivularia sp., Takahashi Hiroki, Iwasaki Arihiro, Ebihara Akira, Taguchi Raimu, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake （Organic Letters） 25 （ 14 ） 2400-2404 Apr. 2023
■Stereochemistry
・Research Objective: Isolation and configuration clarification of Kagimminols A and B, cembrene-type diterpenoids, from an Okeania sp. marine cyanobacterium and evaluation of their biological activity.
- Title: Kagimminols A and B, Cembrene-Type Diterpenes from an Okeania sp. Marine Cyanobacterium, Ebihara Akira, Taguchi Raimu, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake, Iwasaki Arihiro （Journal of Natural Products） 87 （ 4 ） 1116-1123 Apr. 2024
・Research Objective: The objective of the research is the isolation, structure determination, and total synthesis of Hoshinoamide C, an antiparasitic lipopeptide from the marine cyanobacterium Caldora penicillata.
- Title: Isolation, Structure Determination, and Total Synthesis of Hoshinoamide C, an Antiparasitic Lipopeptide from the Marine Cyanobacterium Caldora penicillata, Iwasaki Arihiro, Ohtomo Keisuke, Kurisawa Naoaki, Shiota Ikuma, Rahmawati Yulia, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake （Journal of Natural Products） 84 （ 1 ） 126-135 Jan. 2021
・Research Objective: Isolation and structural determination of linear lipopeptides from the marine cyanobacterium Caldora penicillata.
- Title: Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata, Ozaki Kaori, Jinno Atsuhide, Natsume Noriyuki, Sumimoto Shimpei, Iwasaki Arihiro, Suenaga Kiyotake, Teruya Toshiaki （Tetrahedron） 85 131969 Apr. 2021
■Cell Biology
・Research Objective: To isolate and elucidate the structures of acetylene-containing lipopeptides from an Okeania sp. marine cyanobacterium and evaluate their effects on the differentiation of mouse 3T3-L1 preadipocytes.
- Title: Odookeanynes A and B, Acetylene-Containing Lipopeptides from an Okeania sp. Marine Cyanobacterium, Yamano Aki, Asato Yuka, Natsume Noriyuki, Iwasaki Arihiro, Suenaga Kiyotake, Teruya Toshiaki （Journal of Natural Products） 85 （ 1 ） 169-175 Jan. 2022
・Research Objective: Isolation and structural determination of new macrolide glycosides from a marine cyanobacterium and evaluation of their inhibitory effects on osteoclast formation.
- Title: Irijimasides A–E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium, Yamano Aki, Natsume Noriyuki, Yamada Miki, Sumimoto Shimpei, Iwasaki Arihiro, Suenaga Kiyotake, Teruya Toshiaki （Journal of Natural Products） 83 （ 5 ） 1585-1591 May. 2020
・Research Objective: Isolation, biological activity investigation, and catalytic asymmetric total synthesis of cytotoxic macrolides from the marine cyanobacterium Leptolyngbya sp.
- Title: Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis, Cui Jin, Morita Maho, Ohno Osamu, Kimura Tomoyuki, Teruya Toshiaki, Watanabe Takumi, Suenaga Kiyotake, Shibasaki Masakatsu （Chemistry – A European Journal） 23 （ 35 ） 8500-8509 Jun. 2017
■Protein Identification
・Research Objective: To identify and characterize the binding mode and inhibitory potency of biselyngbyasides on Ca2+-pumps.
- Title: Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+ pumps with a unique mode of binding, Morita Maho, Ogawa Haruo, Ohno Osamu, Yamori Takao, Suenaga Kiyotake, Toyoshima Chikashi （FEBS Letters） 589 （ 13 ） 1406-1411 Jun. 2015
・Research Objective: Identification of the intracellular target molecule of kurahyne to elucidate its mode of action.
- Title: Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages, Iwasaki Arihiro, Ohno Osamu, Katsuyama Shun, Morita Maho, Sasazawa Yukiko, Dan Shingo, Simizu Siro, Yamori Takao, Suenaga Kiyotake （Bioorganic & Medicinal Chemistry Letters） 25 （ 22 ） 5295-5298 Nov. 2015
■Therapeutic Evaluation
・Research Objective: Identification of monovalerianester A as an inhibitor of fat accumulation from Valeriana fauriei.
- Title: Isolation of Monovalerianester A, an Inhibitor of Fat Accumulation, from Valeriana Fauriei, Yuki Keiji, Ikeda Mariko, Yoshida Shosuke, Ohno Osamu, Suenaga Kiyotake, Yamada Kaoru, Uemura Daisuke, Miyamoto Kenji （Natural Product Communications） 10 （ 8 ） Aug. 2015
■Biological Activity Evaluation
・Research Objective: Investigation of the allelopathic properties and substances of Osmanthus species for developing sustainable agriculture systems.
- Title: Allelopathic Substances of Osmanthus spp. for Developing Sustainable Agriculture, Kato-Noguchi Hisashi, Hamada Yuri, Kojima Misuzu, Kumagai Sanae, Iwasaki Arihiro, Suenaga Kiyotake （Plants） 12 （ 2 ） 376 Jan. 2023
・Research Objective: To isolate and identify plant-growth inhibitory constituents from Polygonum chinense Linn and evaluate their bioherbicidal potential.
- Title: Isolation and Identification of Plant-Growth Inhibitory Constituents from Polygonum chinense Linn and Evaluation of Their Bioherbicidal Potential, Lun Thang Lam, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi （Plants） 12 （ 7 ） 1577 Apr. 2023
・Research Objective: The objective of the research is the isolation and total synthesis of beru'amide, an antitrypanosomal polyketide from a marine cyanobacterium Okeania sp.
- Title: Isolation and Total Synthesis of Beru’amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp., Taguchi Raimu, Iwasaki Arihiro, Ebihara Akira, Jeelani Ghulam, Nozaki Tomoyoshi, Suenaga Kiyotake （Organic Letters） 24 （ 25 ） 4710-4714 Jul. 2022
■Immunology Research
・Research Objective: To investigate the potential of pectinioside A, a steroidal saponin from the starfish Patiria pectinifera, as an immunological adjuvant stimulating Th2 type immune response.
- Title: Immunological Adjuvant Activity of Pectinioside A, the Steroidal Saponin from the Starfish Patiria pectinifera, Kawase Osamu, Ohno Osamu, Suenaga Kiyotake, Xuan Xuenan （Natural Product Communications） 11 （ 5 ） May. 2016
■Natural Product Chemistry
・Research Objective: To explore the phytotoxic activities of Senna garrettiana leaf extracts and identify active substances for the development of bioherbicides.
- Title: Phytotoxic Effects of Senna garrettiana and Identification of Phytotoxic Substances for the Development of Bioherbicides, Krumsri Ramida, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi （Agriculture） 12 （ 9 ） 1338 Aug. 2022
・Research Objective: Isolation and characterization of motobamide, a new antitrypanosomal cyclic peptide from a marine Leptolyngbya sp. cyanobacterium.
- Title: Motobamide, an Antitrypanosomal Cyclic Peptide from a Leptolyngbya sp. Marine Cyanobacterium, Takahashi Hiroki, Iwasaki Arihiro, Kurisawa Naoaki, Suzuki Ryota, Jeelani Ghulam, Matsubara Teruhiko, Sato Toshinori, Nozaki Tomoyoshi, Suenaga Kiyotake （Journal of Natural Products） 84 （ 5 ） 1649-1655 May. 2021
・Research Objective: Isolation and structural determination of a new cyclic heptapeptide, Lingaoamide, from a Chinese freshwater cyanobacterium and evaluation of its biological activities.
- Title: Lingaoamide, a cyclic heptapeptide from a Chinese freshwater cyanobacterium Oscillatoria sp., Iwasaki Arihiro, Kurisawa Naoaki, Wang Tingting, Li Xiaohui, Luo Haixi, Zhu Chengcong, Patial Gaurav, Yan Xiaojun, He Shan, Luzzatto-Knaan Tal, Tian Fuli, Naman C. Benjamin, Suenaga Kiyotake （Tetrahedron Letters） 75 153214 Jul. 2021
■Material Supply for Research
・Research Objective: The objective of this research is the total synthesis and stereochemical determination of yoshinone A to establish its absolute configuration and provide sufficient amounts for further research.
- Title: Total synthesis and stereochemical determination of yoshinone A, Shinomiya Seiichi, Iwasaki Arihiro, Ohno Osamu, Suenaga Kiyotake （Phytochemistry） 132 109-114 Dec. 2016
■Organic Agriculture Research
・Research Objective: To investigate allelopathic substances in Albizia richardiana leaves and characterize their phytotoxic effects on seedling growth.
- Title: Phytotoxicity of the novel compound 3-hydroxy-4-oxo-
・Research Objective: To isolate and identify the novel compound garcienone from Garcinia xanthochymus and determine its allelopathic potential.
- Title: Garcienone, a Novel Compound Involved in Allelopathic Activity of Garcinia Xanthochymus Hook, Rob Md. Mahfuzur, Iwasaki Arihiro, Suzuki Ryota, Suenaga Kiyotake, Kato-Noguchi Hisashi （Plants） 8 （ 9 ） 301 Aug. 2019
・Research Objective: To explore the phytotoxic properties and identify phytotoxic substances from the aquatic fern Marsilea crenata.
- Title: Isolation and identification of two potential phytotoxic substances from the aquatic fern Marsilea crenata, Islam Md. Shafiqul, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi （Journal of Plant Biology） 60 （ 1 ） 75-81 Feb. 2017
■Soil Chemistry Analysis
・Research Objective: To investigate the involvement of allelopathy in the inhibition of understory growth in Japanese red pine forests.
- Title: Involvement of allelopathy in inhibition of understory growth in red pine forests, Kato-Noguchi Hisashi, Kimura Fukiko, Ohno Osamu, Suenaga Kiyotake （Journal of Plant Physiology） 218 66-73 Nov. 2017
■Chemical Effects Research
・Research Objective: Determination of the absolute configuration and biological activity of Minnamide A, a lipopeptide from the marine cyanobacterium Okeania hirsuta.
- Title: Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta, Sumimoto Shimpei, Kobayashi Masayuki, Sato Rio, Shinomiya Seiichi, Iwasaki Arihiro, Suda Shoichiro, Teruya Toshiaki, Inuzuka Toshiyasu, Ohno Osamu, Suenaga Kiyotake （Organic Letters） 21 （ 4 ） 1187-1190 Feb. 2019
・Research Objective: To explore the allelopathic potential and identify allelochemicals in Eleocharis atropurpurea.
- Title: Allelopathic property and an allelopathic substance in Eleocharis atropurpurea (Retz.), Zaman Farhana, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi （Theoretical and Experimental Plant Physiology） 30 （ 4 ） 347-355 Dec. 2018
■Chemical Identification
・Research Objective: To investigate the allelopathic potential of Marsdenia tenacissima leaves and its active substances for natural weed control in sustainable agriculture.
- Title: Allelopathic Potential of Marsdenia tenacissima (Roxb.) Moon against Four Test Plants and the Biological Activity of Its Allelopathic Novel Compound, 8-Dehydroxy-11β-O-Acetyl-12β-O-Tigloyl-17β-Marsdenin, Moh Seinn Moh, Kurisawa Naoaki, Suenaga Kiyotake, Kato-Noguchi Hisashi （Plants） 12 （ 8 ） 1663 Apr. 2023
Areas of Research
- ・Biomolecular Chemistry
Social Contributions
- ・Advancement in tropical disease treatment: The research on marine cyanobacteria contributes to discovering new compounds for treating diseases like malaria, potentially leading to innovative therapies.
・Development of novel cancer therapies: By identifying bioactive compounds that induce apoptosis in tumor cells, this research offers potential alternatives to existing cancer treatments.
・Biotechnological and pharmaceutical innovations: Understanding marine cyanobacteria's potential for bioactive compound production may lead to new pharmaceuticals and applications in biotechnology.
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