- Researchmap Member ID
- 5000088240
- ORCID
- https://orcid.org/0000-0003-3985-5471
- Keio Researchers Information System (K-RIS)
- Researcher Details - Matsuda, Keiko
Introduction
- Keiko Matsuda is a researcher focusing on the design and development of connector molecules and synapse formation. Her work includes creating novel molecules like Cbln-C1ql and enhancing synaptic plasticity, aiming to restore neuronal circuits and balance neurotransmission.
Achievements
- ■Design and Development of Connector Molecules
・Research Objective: To design and characterize a synthetic synaptic organizer protein that restores glutamatergic neuronal circuits.
- Title: A synthetic synaptic organizer protein restores glutamatergic neuronal circuits, Suzuki Kunimichi, Elegheert Jonathan, Song Inseon, Sasakura Hiroyuki, Senkov Oleg, Matsuda Keiko, Kakegawa Wataru, Clayton Amber J., Chang Veronica T., Ferrer-Ferrer Maura, Miura Eriko, Kaushik Rahul, Ikeno Masashi, Morioka Yuki, Takeuchi Yuka, Shimada Tatsuya, Otsuka Shintaro, Stoyanov Stoyan, Watanabe Masahiko, Takeuchi Kosei, Dityatev Alexander, Aricescu A. Radu, Yuzaki Michisuke （Science） 369 （ 6507 ） Aug. 2020
Research Objective: Development of tools to design molecules with specific functions at synapses to externally regulate neural activity.
Research Objective: To elucidate the significance of activity-dependent synapse formation, plasticity, and motor learning by externally enhancing the formation of the GluD2-Cbln1-Neurexin complex.
■Synapse Formation and Plasticity
・Research Objective: To investigate the role of C1ql1-Bai3 signaling in climbing fiber synapse formation in mature Purkinje cells and its coordination with neuronal activity.
- Title: C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity, Aimi Takahiro, Matsuda Keiko, Yuzaki Michisuke （Molecular Brain） 16 （ 1 ） Jul. 2023
・Research Objective: To highlight the role of C1 q family proteins and their receptors in organizing and modulating synapses in the central nervous system.
- Title: Synapse organization and modulation via C1q family proteins and their receptors in the central nervous system, Matsuda Keiko （Neuroscience Research） 116 46-53 Mar. 2017
・Research Objective: To elucidate the structural and functional integration of GluD receptors within synaptic organizer complexes to understand their role in synaptogenesis and signaling.
- Title: Structural basis for integration of GluD receptors within synaptic organizer complexes, Elegheert Jonathan, Kakegawa Wataru, Clay Jordan E., Shanks Natalie F., Behiels Ester, Matsuda Keiko, Kohda Kazuhisa, Miura Eriko, Rossmann Maxim, Mitakidis Nikolaos, Motohashi Junko, Chang Veronica T., Siebold Christian, Greger Ingo H., Nakagawa Terunaga, Yuzaki Michisuke, Aricescu A. Radu （Science） 353 （ 6296 ） 295-299 Jul. 2016
■Receptor and Signaling Mechanisms
・Research Objective: To investigate the role of kainate receptors in organizing climbing fiber-Purkinje cell synapses and synaptic plasticity in the cerebellum by forming a complex with synaptic organizers.
- Title: Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum, Kakegawa Wataru, Paternain Ana V., Matsuda Keiko, Aller M. Isabel, Iida Izumi, Miura Eriko, Nozawa Kazuya, Yamasaki Tokiwa, Sakimura Kenji, Yuzaki Michisuke, Lerma Juan （Cell Reports） 43 （ 7 ） 114427 Jul. 2024
・Research Objective: To investigate the interaction between Calsyntenin-3 and neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways.
- Title: Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways, Kim Hyeonho, Kim Dongwook, Kim Jinhu, Lee Hee-Yoon, Park Dongseok, Kang Hyeyeon, Matsuda Keiko, Sterky Fredrik H., Yuzaki Michisuke, Kim Jin Young, Choi Se-Young, Ko Jaewon, Um Ji Won （Journal of Biological Chemistry） 295 （ 27 ） 9244-9262 Jul. 2020
・Research Objective: To investigate how C1q-like proteins modulate the clustering and function of kainate-type glutamate receptors at mossy fiber-CA3 synapses in the hippocampus.
- Title: Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins, Matsuda Keiko, Budisantoso Timotheus, Mitakidis Nikolaos, Sugaya Yuki, Miura Eriko, Kakegawa Wataru, Yamasaki Miwako, Konno Kohtarou, Uchigashima Motokazu, Abe Manabu, Watanabe Izumi, Kano Masanobu, Watanabe Masahiko, Sakimura Kenji, Aricescu A. Radu, Yuzaki Michisuke （Neuron） 90 （ 4 ） 752-767 May. 2016
■Genetic and Molecular Tools
・Research Objective: To map the cellular and subcellular localization of endogenous Neuroligin-1 in the cerebellum using epitope-tagging by electroporation-based gene editing with CRISPR/Cas9.
- Title: Cellular and Subcellular Localization of Endogenous Neuroligin-1 in the Cerebellum, Nozawa Kazuya, Hayashi Ayumi, Motohashi Junko, Takeo Yukari H., Matsuda Keiko, Yuzaki Michisuke （The Cerebellum） 17 （ 6 ） 709-721 Dec. 2018
Areas of Research
- ・Medical Pharmacy
・Physiology
Social Contributions
- ・Advancement in Epilepsy Treatment: By understanding the molecular mechanisms of synapse formation and maturation, this research could lead to new treatments for epilepsy, improving the quality of life for those affected.
・Enhanced Understanding of Neural Networks: The research contributes to a deeper understanding of neural network activities, which is crucial for developing interventions for various neurological disorders.
・Potential Treatments for Synaptic Dysfunction: Insights into synapse maturation mechanisms may lead to treatments for neurological disorders related to synaptic dysfunction, offering hope for patients with these conditions.
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