研究者情報 | Keio Research Showcase

Introduction

Tomohisa Sujino's research focuses on immune research in intestinal and liver diseases, intestinal bacteria research, and the inter-organ network of the nerves that control the digestive system. In particular, he aims to use techniques to track single cells in vivo and to clarify interactions from the localization and dynamics of cells through spatiotemporal analysis in order to treat them.

Achievements

■Regulatory T Cells and Immune Regulation
・Research Objective: To investigate how aryl hydrocarbon receptor signals in epithelial cells influence the recruitment and localization of Helios+ Tregs in the gut.
- Title: Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut, Yoshimatsu Yusuke, Sujino Tomohisa, Miyamoto Kentaro, Harada Yosuke, Tanemoto Shun, Ono Keiko, Umeda Satoko, Yoshida Kosuke, Teratani Toshiaki, Suzuki Takahiro, Mikami Yohei, Nakamoto Nobuhiro, Sasaki Nobuo, Takabayashi Kaoru, Hosoe Naoki, Ogata Haruhiko, Sawada Kazuaki, Imamura Takeshi, Yoshimura Akihiko, Kanai Takanori （Cell Reports） 39 （ 6 ） 110773 May. 2022
・Research Objective: To summarize how regulatory T cells (Tregs) are induced in the digestive tract and the application of in vivo Treg imaging to elucidate immune homeostasis in the digestive tract.
- Title: Localization and movement of Tregs in gastrointestinal tract: a systematic review, Harada Yosuke, Miyamoto Kentaro, Chida Akihiko, Okuzawa Anna Tojo, Yoshimatsu Yusuke, Kudo Yumi, Sujino Tomohisa （Inflammation and Regeneration） 42 （ 1 ） Nov. 2022
・Research Objective: To investigate the role of the liver-brain-gut neural arc in maintaining the regulatory T cell niche in the gut.
- Title: The liver–brain–gut neural arc maintains the Treg cell niche in the gut, Teratani Toshiaki, Mikami Yohei, Nakamoto Nobuhiro, Suzuki Takahiro, Harada Yosuke, Okabayashi Koji, Hagihara Yuya, Taniki Nobuhito, Kohno Keita, Shibata Shinsuke, Miyamoto Kentaro, Ishigame Harumichi, Chu Po-Sung, Sujino Tomohisa, Suda Wataru, Hattori Masahira, Matsui Minoru, Okada Takaharu, Okano Hideyuki, Inoue Masayuki, Yada Toshihiko, Kitagawa Yuko, Yoshimura Akihiko, Tanida Mamoru, Tsuda Makoto, Iwasaki Yusaku, Kanai Takanori （Nature） 585 （ 7826 ） 591-596 Sep. 2020
■Intestinal and Liver Diseases
・Research Objective: To investigate the emergence of macrophages and dendritic cells in the liver during intestinal inflammation and their role in predisposing the liver to inflammation.
- Title: Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation, Mikami Yohei, Mizuno Shinta, Nakamoto Nobuhiro, Hayashi Atsushi, Sujino Tomohisa, Sato Toshiro, Kamada Nobuhiko, Matsuoka Katsuyoshi, Hisamatsu Tadakazu, Ebinuma Hirotoshi, Hibi Toshifumi, Yoshimura Akihiko, Kanai Takanori （PLoS ONE） 9 （ 1 ） e84619 Jan. 2014
・Research Objective: To investigate the ability of intrarectally administered dendritic cells to penetrate the intestinal barrier and influence intestinal immune tolerance via a Th2-mediated response in mice.
- Title: Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice, Handa Tango, Kanai Takanori, Sato Toshiro, Mikami Yohei, Sujino Tomohisa, Hayashi Atsushi, Mizuno Shinta, Matsumoto Atsuhiro, Hisamatsu Tadakazu, Hibi Toshifumi （Immunology Letters） 150 （ 1-2 ） 123-129 Feb. 2013
■Colitis and Inflammatory Bowel Disease
・Research Objective: To investigate the impact of Toll-like receptor 7 agonist-induced dermatitis on dextran sulfate sodium colitis through alterations in the gut microbiome and immune cells.
- Title: Toll-Like Receptor 7 Agonist–Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells, Kiyohara Hiroki, Sujino Tomohisa, Teratani Toshiaki, Miyamoto Kentaro, Arai Mari Mochizuki, Nomura Ena, Harada Yosuke, Aoki Ryo, Koda Yuzo, Mikami Yohei, Mizuno Shinta, Naganuma Makoto, Hisamatsu Tadakazu, Kanai Takanori （Cellular and Molecular Gastroenterology and Hepatology） 7 （ 1 ） 135-156
・Research Objective: To investigate the protective role of plasmacytoid dendritic cells in immune-mediated acute liver injury via IL-35.
- Title: Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35, Koda Yuzo, Nakamoto Nobuhiro, Chu Po-Sung, Ugamura Aya, Mikami Yohei, Teratani Toshiaki, Tsujikawa Hanako, Shiba Shunsuke, Taniki Nobuhito, Sujino Tomohisa, Miyamoto Kentaro, Suzuki Takahiro, Yamaguchi Akihiro, Morikawa Rei, Sato Katsuaki, Sakamoto Michiie, Yoshimoto Takayuki, Kanai Takanori （Journal of Clinical Investigation） 129 （ 8 ） 3201-3213 Jul. 2019
・Research Objective: To search for new probiotic candidates for inflammatory bowel disease by analyzing the intestinal microbiota of ulcerative colitis patients and clarifying their effects on inflammation.
- Title: A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients, Takeshita Kozue, Mizuno Shinta, Mikami Yohei, Sujino Tomohisa, Saigusa Keiichiro, Matsuoka Katsuyoshi, Naganuma Makoto, Sato Tadashi, Takada Toshihiko, Tsuji Hirokazu, Kushiro Akira, Nomoto Koji, Kanai Takanori （Inflammatory Bowel Diseases） 22 （ 12 ） 2802-2810 Dec. 2016
■Gastrointestinal Endoscopy and Imaging
・Research Objective: To summarize and focus on the current status of colon capsule endoscopy for colorectal cancer screening and its potential applicability to inflammatory bowel disease.
- Title: Current status of colon capsule endoscopy, Hosoe Naoki, Limpias Kamiya Kenji J. L., Hayashi Yukie, Sujino Tomohisa, Ogata Haruhiko, Kanai Takanori （Digestive Endoscopy） 33 （ 4 ） 529-537 May. 2021
・Research Objective: To summarize the clinical and endoscopic characteristics of pyogenic granuloma in the small intestine through a case series and literature review.
- Title: Clinical and Endoscopic Characteristics of Pyogenic Granuloma in the Small Intestine: A Case Series with Literature Review, Hayashi Yukie, Hosoe Naoki, Takabayashi Kaoru, Kamiya Kenji JL Limpias, Mutaguchi Makoto, Miyanaga Ryoichi, Hirata Kenro, Fukuhara Seiichiro, Mikami Yohei, Sujino Tomohisa, Masugi Yohei, Naganuma Makoto, Ogata Haruhiko, Kanai Takanori （Internal Medicine） 59 （ 4 ） 501-505 Feb. 2020
・Research Objective: To investigate differences in mucosal concentrations of 5-ASA and Ac-5-ASA according to endoscopic activity in ulcerative colitis patients treated with mesalamine.
- Title: Mucosal concentrations of N‐acetyl‐5‐aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine, Fukuda Tomohiro, Naganuma Makoto, Takabayashi Kaoru, Hagihara Yuya, Tanemoto Shun, Nomura Ena, Yoshimatsu Yusuke, Sugimoto Shinya, Nanki Kosaku, Mizuno Shinta, Mikami Yohei, Fukuhara Kayoko, Sujino Tomohisa, Mutaguchi Makoto, Inoue Nagamu, Ogata Haruhiko, Iwao Yasushi, Abe Takayuki, Kanai Takanori （Journal of Gastroenterology and Hepatology） 35 （ 11 ） 1878-1885 Nov. 2020
■Dental and Oral Health
・Research Objective: To investigate masticatory function and gastric emptying rate in subjects with malocclusion.
- Title: Gastric emptying rate in subjects with malocclusion examined by [¹³C] breath test, Koike Sarina, Sujino Tomohisa, Ohmori Hiroko, Shimazaki Kazuo, Fukuyama Eiji, Kanai Takanori, Hibi Toshifumi, Ono Takashi （Orthodontic Waves） 73 （ 4 ） 1-1 Dec. 2014
■Inflammatory and Immune Responses
・Research Objective: To assess the intestinal epithelial structure using scanning electron microscopy in patients with ulcerative colitis who are in remission.
- Title: Characteristics of the Mucosal Surface on Scanning Electron Microscopy in Patients with Remitting Ulcerative Colitis, Nomura Ena, Sujino Tomohisa, Hosoe Naoki, Yoshimatsu Yusuke, Tanemoto Shun, Takabayashi Kaoru, Mutaguchi Makoto, Shimoda Masayuki, Naganuma Makoto, Ogata Haruhiko, Kanai Takanori （Digestive Diseases and Sciences） 66 （ 9 ） 3141-3148 Sep. 2021
・Research Objective: To investigate the relationship between preexisting inflammatory bowel disease and the development of immune-mediated colitis in patients treated with immune checkpoint inhibitors.
- Title: Ulcerative colitis exacerbation after the onset of immune checkpoint inhibitor related colitis, Kayashima Atsuto, Shimozaki Keitaro, Hirata Kenro, Mutaguchi Makoto, Takabayashi Kaoru, Hayashi Yuichiro, Hosoe Naoki, Ogata Haruhiko, Sujino Tomohisa, Kanai Takanori （Clinical Journal of Gastroenterology） 14 （ 1 ） 152-158 Feb. 2021
・Research Objective: To clarify the clinical impact of assessing deep small bowel lesions using balloon-assisted enteroscopy on Crohn's disease patients in clinical remission.
- Title: Significance of endoscopic deep small bowel evaluation using balloon-assisted enteroscopy for Crohn’s disease in clinical remission, Takabayashi Kaoru, Hosoe Naoki, Kato Motohiko, Hayashi Yukie, Nanki Kosaku, Fukuhara Kayoko, Mikami Yohei, Mizuno Shinta, Sujino Tomohisa, Mutaguchi Makoto, Naganuma Makoto, Yahagi Naohisa, Ogata Haruhiko, Kanai Takanori （Journal of Gastroenterology） 56 （ 1 ） 25-33 Jan. 2021
■Cellular and Molecular Mechanisms
・Research Objective: To investigate how the gut epithelial microenvironment alters CD4(+) T cells during their conversion into intraepithelial lymphocytes through chromatin accessibility and transcription changes.
- Title: Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program, London Mariya, Bilate Angelina M., Castro Tiago B. R., Sujino Tomohisa, Mucida Daniel （Nature Immunology） 22 （ 4 ） 449-459 Apr. 2021
・Research Objective: To investigate the role of CD8(+) tissue-resident memory T cells in promoting liver fibrosis resolution by inducing apoptosis of hepatic stellate cells.
- Title: CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells, Koda Yuzo, Teratani Toshiaki, Chu Po-Sung, Hagihara Yuya, Mikami Yohei, Harada Yosuke, Tsujikawa Hanako, Miyamoto Kentaro, Suzuki Takahiro, Taniki Nobuhito, Sujino Tomohisa, Sakamoto Michiie, Kanai Takanori, Nakamoto Nobuhiro （Nature Communications） 12 （ 1 ） Jul. 2021
■Endoscopic Interventions and Procedures
・Research Objective: To evaluate the feasibility and safety of endoscopic ischemic polypectomy and the clinical outcomes in patients with Peutz-Jeghers syndrome.
- Title: Feasibility and Safety of Endoscopic Ischemic Polypectomy and Clinical Outcomes in Patients with Peutz–Jeghers Syndrome (with Video), Limpias Kamiya Kenji J. L., Hosoe Naoki, Takabayashi Kaoru, Okuzawa Anna, Sakurai Hinako, Hayashi Yukie, Miyanaga Ryoichi, Sujino Tomohisa, Ogata Haruhiko, Kanai Takanori （Digestive Diseases and Sciences） 68 （ 1 ） 252-258 Jan. 2023
・Research Objective: To identify the indications for endoscopic intervention in patients with Crohn's disease and small bowel stenosis.
- Title: Predictors of necessity for endoscopic balloon dilatation in patients with Crohn’s disease-related small bowel stenosis, Hayashi Yukie, Takabayashi Kaoru, Hosoe Naoki, Kiyohara Hiroki, Kinoshita Satoshi, Nanki Kosaku, Fukuhara Kayoko, Mikami Yohei, Sujino Tomohisa, Mutaguchi Makoto, Kawaguchi Takaaki, Kato Motohiko, Ogata Haruhiko, Kanai Takanori （Annals of Medicine） 53 （ 1 ） 2025-2033 Jan. 2021
・Research Objective: To report and summarize the various endoscopic features and characteristics of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) using single balloon endoscopy.
- Title: Various Endoscopic Features in Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma, Aoki Yasuhiro, Sujino Tomohisa, Takabayashi Kaoru, Mutakuchi Makoto, Emoto Katsura, Hosoe Naoki, Ogata Haruhiko, Kanai Takanori （Case Reports in Gastroenterology） 15 （ 1 ） 312-322 Mar. 2021
■Metabolic and Hypoxic Adaptations
・Research Objective: To investigate the metabolic adaptation and gene modulation of intraepithelial CD4+CD8αα+ T lymphocytes in hypoxic environments.
- Title: Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes, Harada Yosuke, Sujino Tomohisa, Miyamoto Kentaro, Nomura Ena, Yoshimatsu Yusuke, Tanemoto Shun, Umeda Satoko, Ono Keiko, Mikami Yohei, Nakamoto Nobuhiro, Takabayashi Kaoru, Hosoe Naoki, Ogata Haruhiko, Ikenoue Tuneo, Hirao Atsushi, Kubota Yoshiaki, Kanai Takanori （iScience） 25 （ 4 ） 104021 Apr. 2022
■Therapeutic Efficacy and Safety
・Research Objective: To evaluate the effectiveness and durability of ustekinumab therapy with or without thiopurine immunomodulators for ulcerative colitis in Japanese patients.
- Title: Effectiveness and Durability of Ustekinumab Therapy With or Without Immunomodulators for Ulcerative Colitis Patients in Japan, Aoki Yasuhiro, Sujino Tomohisa, Kawaguchi Takaaki, Sugimoto Shinya, Shimada Fumie, Yoshimatsu Yusuke, Kiyohara Hiroki, Nanki Kosaku, Mikami Yohei, Takabayashi Kaoru, Hosoe Naoki, Ogata Haruhiko, Iwao Yasushi, Kanai Takanori （Crohn's & Colitis 360） 4 （ 2 ） Apr. 2022
・Research Objective: To evaluate the efficacy of calcineurin inhibitors for induction of remission in patients with active intestinal Behcet's disease.
- Title: Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet’s Disease, Kawaguchi Takaaki, Fukata Masayuki, Omori Teppei, Kiyohara Hiroki, Sugimoto Shinya, Nanki Kosaku, Sujino Tomohisa, Mikami Yohei, Kanai Takanori （Crohn's & Colitis 360） 4 （ 3 ） Jul. 2022
・Research Objective: To investigate the clinical impact of capnography and bispectral index monitoring on hypoxic events during oral therapeutic and invasive endoscopic procedures.
- Title: Efficacy of capnographic and bispectral index monitoring on trans‐oral therapeutic endoscopy: A prospective observational study, Hayashi Yukie, Hosoe Naoki, Takabayashi Kaoru, Limpias Kamiya Kenji J. L., Tojo Anna, Sakurai Hinako, Kinoshita Satoshi, Sujino Tomohisa, Nakayama Atsushi, Kato Motohiko, Yahagi Naohisa, Ogata Haruhiko, Kanai Takanori （Journal of Gastroenterology and Hepatology） 37 （ 10 ） 2004-2010 Oct. 2022
■Innate Lymphoid Cells and Cytokines
・Research Objective: To investigate the role of type I interferon signaling in group 2 innate lymphoid cells during experimental colitis.
- Title: Enrichment of type I interferon signaling in colonic group 2 innate lymphoid cells in experimental colitis, Irie Emi, Ishihara Rino, Mizushima Ichiro, Hatai Shunya, Hagihara Yuya, Takada Yoshiaki, Tsunoda Junya, Iwata Kentaro, Matsubara Yuta, Yoshimatsu Yusuke, Kiyohara Hiroki, Taniki Nobuhito, Sujino Tomohisa, Takabayashi Kaoru, Hosoe Naoki, Ogata Haruhiko, Teratani Toshiaki, Nakamoto Nobuhiro, Mikami Yohei, Kanai Takanori （Frontiers in Immunology） 13 Oct. 2022
■Genetic and Protein Expression
・Research Objective: To evaluate the efficacy of immunohistochemical staining with SLCO2A1 polyclonal antibody as a pre-diagnostic tool for chronic enteropathy associated with SLCO2A1.
- Title: Chronic Enteropathy Associated with <i>Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1)</i> with Positive Immunohistochemistry for SLCO2A1 Protein, Ariake Chizuru, Hosoe Naoki, Sakurai Hinako, Tojo Anna, Hayashi Yukie, JL Limpias Kamiya Kenji, Sujino Tomohisa, Takabayashi Kaoru, Kosaki Kenjiro, Seki Satowa, Hisamatsu Tadakazu, Ogata Haruhiko, Kanai Takanori （Internal Medicine） 61 （ 17 ） 2607-2611 Sep. 2022
■Cytotoxic T Cells and Immune Responses
・Research Objective: To identify cytotoxic CD4(+) T cells in the human intestine and analyze their characteristics in patients with inflammatory bowel disease using single-cell RNA-seq.
- Title: Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells, Tanemoto Shun, Sujino Tomohisa, Miyamoto Kentaro, Moody Jonathan, Yoshimatsu Yusuke, Ando Yoshinari, Koya Ikuko, Harada Yosuke, Tojo Anna Okuzawa, Ono Keiko, Hayashi Yukie, Takabayashi Kaoru, Okabayashi Koji, Teratani Toshiaki, Mikami Yohei, Nakamoto Nobuhiro, Hosoe Naoki, Ogata Haruhiko, Hon Chung-Chau, Shin Jay W., Kanai Takanori （Frontiers in Immunology） 13 Oct. 2022
■Hydrogen Gas and Oxidative Stress
・Research Objective: To clarify the treatment effects and target cells of hydrogen gas for mesenteric ischemia.
- Title: Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion, Yamamoto Ryo, Suzuki Sayuri, Homma Koichiro, Yamaguchi Shintaro, Sujino Tomohisa, Sasaki Junichi （World Journal of Gastrointestinal Surgery） 14 （ 12 ） 1329-1339 Dec. 2022
■Venous Thromboembolism and Risk Factors
・Research Objective: To identify the risk of venous thromboembolism with central venous catheter placement in hospitalized Japanese patients with inflammatory bowel disease without thromboprophylaxis.
- Title: Risk of venous thromboembolism with a central venous catheter in hospitalized Japanese patients with inflammatory bowel disease: a propensity score-matched cohort study, Aoki Yasuhiro, Kiyohara Hiroki, Mikami Yohei, Nanki Kosaku, Kawaguchi Takaaki, Yoshimatsu Yusuke, Sugimoto Shinya, Sujino Tomohisa, Takabayashi Kaoru, Hosoe Naoki, Ogata Haruhiko, Iwao Yasushi, Kanai Takanori （Intestinal Research） 21 （ 3 ） 318-327 Jul. 2023
■Ulcerative Colitis and Inflammation
・Research Objective: To clarify the usefulness of texture and color enhancement imaging (TXI) in the assessment of inflammation in patients with ulcerative colitis.
- Title: Usefulness of texture and color enhancement imaging in assessing mucosal healing in patients with ulcerative colitis, Hayashi Yukie, Takabayashi Kaoru, Kato Motohiko, Tojo Anna, Aoki Yasuhiro, Hagihara Yuya, Yoshida Kosuke, Yoshimatsu Yusuke, Kiyohara Hiroki, Sugimoto Shinya, Nanki Kosaku, Mikami Yohei, Sujino Tomohisa, Mutaguchi Makoto, Kawaguchi Takaaki, Hosoe Naoki, Yahagi Naohisa, Ogata Haruhiko, Kanai Takanori （Gastrointestinal Endoscopy） 97 （ 4 ） 759-766.e1 Apr. 2023
■Human Gut Cell Atlas and Research Integration
・Research Objective: To provide a structured and coordinated roadmap for the generation of the first comprehensive Human Gut Cell Atlas by aligning global research efforts.
- Title: A Roadmap for the Human Gut Cell Atlas, Zilbauer Matthias, James Kylie R., Kaur Mandeep, Pott Sebastian, Li Zhixin, Burger Albert, Thiagarajah Jay R., Burclaff Joseph, Jahnsen Frode L., Perrone Francesca, Ross Alexander D., Matteoli Gianluca, Stakenborg Nathalie, Sujino Tomohisa, Moor Andreas, Bartolome-Casado Raquel, Bækkevold Espen S., Zhou Ran, Xie Bingqing, Lau Ken S., Din Shahida, Magness Scott T., Yao Qiuming, Beyaz Semir, Arends Mark, Denadai-Souza Alexandre, Coburn Lori A., Gaublomme Jellert T., Baldock Richard, Papatheodorou Irene, Ordovas-Montanes Jose, Boeckxstaens Guy, Hupalowska Anna, Teichmann Sarah A., Regev Aviv, Xavier Ramnik J., Simmons Alison, Snyder Michael P., Wilson Keith T., , （Nature Reviews Gastroenterology & Hepatology） 20 （ 9 ） 597-614 Sep. 2023
■Ulcerative Colitis and Neoplasia
・Research Objective: To describe the main diagnostic patterns for ulcerative colitis-associated neoplasia using chromoendoscopic imaging with indigo carmine dye spraying.
- Title: Characteristics of flat‐type ulcerative colitis‐associated neoplasia on chromoendoscopic imaging with indigo carmine dye spraying, Takabayashi Kaoru, Sugimoto Shinya, Nanki Kosaku, Yoshimatsu Yusuke, Kiyohara Hiroki, Mikami Yohei, Sujino Tomohisa, Kato Motohiko, Hosoe Naoki, Shimoda Masayuki, Yahagi Naohisa, Ogata Haruhiko, Iwao Yasushi, Kanai Takanori （Digestive Endoscopy） 36 （ 4 ） 446-454 Apr. 2024
■Intestinal Epithelial Cells and Gene Expression
・Research Objective: To investigate the role of chemokine receptor 9 downregulation in the development of CD4(+)CD8aa(+) intraepithelial lymphocytes.
- Title: Downregulation of chemokine receptor 9 facilitates CD4+CD8αα+ intraepithelial lymphocyte development, Ono Keiko, Sujino Tomohisa, Miyamoto Kentaro, Harada Yosuke, Kojo Satoshi, Yoshimatsu Yusuke, Tanemoto Shun, Koda Yuzo, Zheng Jiawen, Sayama Kazutoshi, Koide Tsuyoshi, Teratani Toshiaki, Mikami Yohei, Takabayashi Kaoru, Nakamoto Nobuhiro, Hosoe Naoki, London Mariya, Ogata Haruhiko, Mucida Daniel, Taniuchi Ichiro, Kanai Takanori （Nature Communications） 14 （ 1 ） Aug. 2023
■Microbiota and Immune System Interactions
・Research Objective: To investigate the role of gut microbiota-induced kynurenic acid in recruiting GPR35-positive macrophages to promote experimental encephalitis.
- Title: The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis, Miyamoto Kentaro, Sujino Tomohisa, Harada Yosuke, Ashida Hiroshi, Yoshimatsu Yusuke, Yonemoto Yuki, Nemoto Yasuhiro, Tomura Michio, Melhem Hassan, Niess Jan Hendrik, Suzuki Toshihiko, Suzuki Toru, Suzuki Shohei, Koda Yuzo, Okamoto Ryuichi, Mikami Yohei, Teratani Toshiaki, Tanaka Kenji F., Yoshimura Akihiko, Sato Toshiro, Kanai Takanori （Cell Reports） 42 （ 8 ） 113005 Aug. 2023
■T Cell Induction and Hypoxic Environments
・Research Objective: To develop a protocol for isolating and enriching mouse splenic naive CD4+ T cells for in vitro induction of CD4+CD8aa+ cells.
- Title: Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction, Harada Yosuke, Miyamoto Kentaro, Sujino Tomohisa （STAR Protocols） 3 （ 4 ） 101728 Dec. 2022
■Amino Acids and Gut Microbiota
・Research Objective: To investigate the potential therapeutic role of D-amino acids in ameliorating experimental colitis and cholangitis by inhibiting the growth of Proteobacteria.
- Title: D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease, Umeda Satoko, Sujino Tomohisa, Miyamoto Kentaro, Yoshimatsu Yusuke, Harada Yosuke, Nishiyama Keita, Aoto Yoshimasa, Adachi Keika, Hayashi Naoki, Amafuji Kimiko, Moritoki Nobuko, Shibata Shinsuke, Sasaki Nobuo, Mita Masashi, Tanemoto Shun, Ono Keiko, Mikami Yohei, Sasabe Jumpei, Takabayashi Kaoru, Hosoe Naoki, Suzuki Toshihiko, Sato Toshiro, Atarashi Koji, Teratani Toshiaki, Ogata Haruhiko, Nakamoto Nobuhiro, Shiomi Daisuke, Ashida Hiroshi, Kanai Takanori （Cellular and Molecular Gastroenterology and Hepatology） 16 （ 6 ） 1011-1031
■Gastrointestinal Symptoms and COVID-19
・Research Objective: To investigate the cause of fever and increased inflammatory response across multiple organs after endoscopic resection.
- Title: Prospective cross‐organ analysis for the causes of fever and increased inflammatory response after endoscopic resection, Mizutani Mari, Minesaki Daisuke, Morioka Kohei, Iwata Kentaro, Miyazaki Kurato, Masunaga Teppei, Kubosawa Yoko, Hayashi Yukie, Sasaki Motoki, Akimoto Teppei, Takatori Yusaku, Matsuura Noriko, Nakayama Atsushi, Sujino Tomohisa, Takabayashi Kaoru, Kanai Takanori, Yahagi Naohisa, Kato Motohiko （Digestive Endoscopy） 36 （ 8 ） 918-926 Aug. 2024
・Research Objective: To clarify any associations between gastrointestinal symptoms and the prognosis of COVID-19.
- Title: Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study, Matsubara Yuta, Kiyohara Hiroki, Mikami Yohei, Nanki Kosaku, Namkoong Ho, Chubachi Shotaro, Tanaka Hiromu, Azekawa Shuhei, Sugimoto Shinya, Yoshimatsu Yusuke, Sujino Tomohisa, Takabayashi Kaoru, Hosoe Naoki, Sato Toshiro, Ishii Makoto, Hasegawa Naoki, Okada Yukinori, Koike Ryuji, Kitagawa Yuko, Kimura Akinori, Imoto Seiya, Miyano Satoru, Ogawa Seishi, Fukunaga Koichi, Kanai Takanori, , Chubachi Shotaro, Namkoong Ho, Fukushima Takahiro, Tanaka Hiromu, Lee Ho, Otake Shiro, Nakagawara Kensuke, Morita Atsuho, Watase Mayuko, Sakurai Kaori, Ogawa Takunori, Kusumoto Takuya, Masaki Katsunori, Kabata Hiroki, Ikemura Shinnosuke, Okamori Satoshi, Terai Hideki, Kamata Hirofumi, Uchida Sho, Uno Shunsuke, Hasegawa Naoki, Takahashi Kazuhisa, Sasano Hitoshi, Kitagawa Yuko, Harada Norihiro, Takagi Haruhi, Nakamura Ai, Naito Toshio, Hiki Makoto, Matsushita Yasushi, Aoki Ryousuke, Harada Sonoko, Sasaki Junichi, Morisaki Hiroshi, Uwamino Yoshifumi, Nanki Kosaku, Mikami Yohei, Ishihara Rino, Matsubara Yuta, Kiyohara Hiroki, Sugimoto Shinya, Yoshimatsu Yusuke, Nishimura Tomoyasu, Sato Toshiro, Ueda Tetsuya, Azuma Masanori, Saito Ryuichi, Sado Toshikatsu, Miyazaki Yoshimune, Sato Ryuichi, Haruta Yuki, Nagasaki Tadao, Hasegawa Yoshinori, Yasui Yoshinori, Ueda Soichiro, Tada Ai, Miyawaki Masayoshi, Yamamoto Masaomi, Yoshida Eriko, Hayashi Reina, Nagasaka Tomoki, Arai Sawako, Kaneko Yutaro, Sasaki Kana, Ishiguro Takashi, Isono Taisuke, Shibata Shun, Matsui Yuma, Hosoda Chiaki, Takano Kenji, Nishida Takashi, Kobayashi Yoichi, Takaku Yotaro, Takayanagi Noboru, Tagaya Etsuko, Arimura Ken, Kawana Masatoshi, Nakamori Yasushi, Yoshiya Kazuhisa, Saito Fukuki, Yoshihara Tomoyuki, Wada Daiki, Iwamura Hiromu, Kanayama Syuji, Maruyama Shuhei, Hasegawa Takanori, Takahashi Kunihiko, Anzai Tatsuhiko, Ito Satoshi, Endo Akifumi, Uchimura Yuji, Miyazaki Yasunari, Honda Takayuki, Tateishi Tomoya, Tohda Shuji, Ichimura Naoya, Sonobe Kazunari, Sassa Chihiro Tani, Nakajima Jun, Ai Masumi, Yoshiyama Takashi, Ohta Ken, Kokuto Hiroyuki, Ogata Hideo, Tanaka Yoshiaki, Arakawa Kenichi, Shimoda Masafumi, Osawa Takeshi, Nakano Yasushi, Nakajima Yukiko, Anan Ryusuke, Arai Ryosuke, Kurihara Yuko, Harada Yuko, Nishio Kazumi, Mutoh Yoshikazu, Sato Tomonori, Takei Reoto, Hagimoto Satoshi, Noguchi Yoichiro, Yamano Yasuhiko, Sasano Hajime, Ota Sho, Suzuki Yusuke, Nakayama Sohei, Masuzawa Keita, Asakura Takanori, Takano Tomomi, Katayama Kazuhiko, Murakami Koji, Yamada Mitsuhiro, Sugiura Hisatoshi, Sano Hirohito, Matsumoto Shuichiro, Kimura Nozomu, Ono Yoshinao, Baba Hiroaki, Baba Rie, Arai Daisuke, Ogura Takayuki, Takahashi Hidenori, Hagiwara Shigehiro, Nagao Genta, Konishi Shunichiro, Nakachi Ichiro, Tateno Hiroki, Hase Isano, Yoshida Shuichi, Suzuki Shoji, Kawada Miki, Horinouchi Hirohisa, Saito Fumitake, Ochi Junichi, Mitamura Keiko, Hagihara Masao, Uchida Tomoyuki, Shiroyama Takayuki, Maeda Yuichi, Nii Takuro, Noda Yoshimi, Niitsu Takayuki, Adachi Yuichi, Enomoto Takatoshi, Amiya Saori, Hara Reina, Edahiro Ryuya, Shirai Yuya, Naito Tatsuhiko, Yamamoto Kenichi, Hirata Haruhiko, Takeda Yoshito, Namba Shinichi, Suzuki Ken, Sonehara Kyuto, Sasa Noa, Ueno Yuya, Suzuki Motoyuki, Takemoto Norihiko, Eguchi Hirotaka, Fukusumi Takahito, Imai Takao, Inohara Hidenori, Kishikawa Toshihiro, Yamada Shuhei, Kawabata Shuhei, Kijima Noriyuki, Kishima Haruhiko, Sujino Tomohisa, Takabayashi Kaoru, Hosoe Naoki, Tomono Kazunori, Kato Kazuto, Fukushima Munehisa, Takagaki Masatoshi, Kumanogoh Atsushi, Miyazawa Naoki, Kimura Yasuhiro, Sado Reiko, Sugimoto Hideyasu, Kamiya Akane, Kuwahara Naota, Fujiwara Akiko, Matsunaga Tomohiro, Sato Yoko, Okada Takenori, Inoue Takashi, Hirano Toshiyuki, Kobayashi Keigo, Takaoka Hatsuyo, Nishi Koichi, Nishitsuji Masaru, Tani Mayuko, Suzuki Junya, Nakatsumi Hiroki, Koh Hidefumi, Manabe Tadashi, Funatsu Yohei, Ito Fumimaro, Fukui Takahiro, Shinozuka Keisuke, Kohashi Sumiko, Miyazaki Masatoshi, Shoko Tomohisa, Kojima Mitsuaki, Adachi Tomohiro, Ishikawa Motonao, Takahashi Kenichiro, Watanabe Kazuyoshi, Hirai Yoshihiro, Kawashima Hidetoshi, Narita Atsuya, Niwa Kazuki, Sekikawa Yoshiyuki, Sageshima Hisako, Nakamura Yoshihiko, Hoshino Kota, Maruyama Junichi, Ishikura Hiroyasu, Takata Tohru, Ogura Takashi, Kitamura Hideya, Hagiwara Eri, Murohashi Kota, Okabayashi Hiroko, Nukaga Shigenari, Satomi Ryosuke, Mochimaru Takao, Oyamada Yoshitaka, Mori Nobuaki, Baba Tomoya, Fukui Yasutaka, Odate Mitsuru, Mashimo Shuko, Makino Yasushi, Yagi Kazuma, Hashiguchi Mizuha, Kagyo Junko, Shiomi Tetsuya, Kawamura Kodai, Ichikado Kazuya, Nishiyama Kenta, Muranaka Hiroyuki, Nakamura Kazunori, Fuke Satoshi, Saito Hiroshi, Tsuchida Tomoya, Fujitani Shigeki, Takita Mumon, Morikawa Daiki, Yoshida Toru, Izumo Takehiro, Inomata Minoru, Kuse Naoyuki, Awano Nobuyasu, Tone Mari, Ito Akihiro, Odani Toshio, Amishima Masaru, Hattori Takeshi, Shichinohe Yasuo, Kagaya Takashi, Kita Toshiyuki, Ohta Kazuhide, Sakagami Satoru, Koshida Kiyoshi, Nakamura Morio, Yokote Koutaro, Nakada Taka-Aki, Abe Ryuzo, Oshima Taku, Shimada Tadanaga, Hayashi Kentaro, Shimizu Tetsuo, Kozu Yutaka, Hiranuma Hisato, Gon Yasuhiro, Izumi Namiki, Nagata Kaoru, Ueda Ken, Taki Reiko, Hanada Satoko, Ishii Makoto, Hashimoto Naozumi, Wakahara Keiko, Sakamoto Koji, Omote Norihito, Ando Akira, Kusaka Yu, Ohba Takehiko, Isogai Susumu, Ogawa Aki, Inoue Takuya, Kodama Nobuhiro, Kaneyama Yasunari, Maeda Shunsuke, Kuraki Takashige, Matsumoto Takemasa, Harada Masahiro, Takahashi Takeshi, Ono Hiroshi, Sakurai Toshihiro, Shibusawa Takayuki, Kawamura Yusuke, Nakayama Akiyoshi, Matsuo Hirotaka, Kimizuka Yoshifumi, Kawana Akihiko, Sano Tomoya, Watanabe Chie, Suematsu Ryohei, Masuda Makoto, Wakabayashi Aya, Watanabe Hiroki, Ueda Suguru, Nishikawa Masanori, Yoshifuji Ayumi, Ito Kazuto, Takahashi Saeko, Ishioka Kota, Chihara Yusuke, Takeuchi Mayumi, Onoi Keisuke, Shinozuka Jun, Sueyoshi Atsushi, Nagasaki Yoji, Okamoto Masaki, Tokunaga Yoshihisa, Ishihara Sayoko, Shimo Masatoshi, Watanabe Masafumi, Inoue Sumito, Igarashi Akira, Sato Masamichi, Hizawa Nobuyuki, Inoue Yoshiaki, Chiba Shigeru, Yamagata Kunihiro, Kai Hirayasu, Hiramatsu Yuji, Fukuyama Satoru, Kano Keiko, Matsumoto Koichiro, Eriguchi Yoshihiro, Yonekawa Akiko, Kanaoka Kensuke, Ihara Shoichi, Komuta Kiyoshi, Asano Koichiro, Oguma Tsuyoshi, Ito Yoko, Hashimoto Satoru, Yamasaki Masaki, Kasamatsu Yu, Komase Yuko, Hida Naoya, Tsuburai Takahiro, Oyama Baku, Kitagawa Yuichiro, Fukuta Tetsuya, Miyake Takahito, Yoshida Shozo, Ogura Shinji, Takada Minoru, Kanda Hidenori, Abe Shinji, Kono Yuta, Togashi Yuki, Takoi Hiroyuki, Kikuchi Ryota, Ogawa Shinichi, Ogata Tomouki, Ishihara Shoichiro, Ozaki Shinji, Fuchimoto Yasuko, Wada Sae, Kanehiro Arihiko, Fujimoto Nobukazu, Nishiyama Kei, Terashima Mariko, Beppu Satoru, Yoshida Kosuke, Narumoto Osamu, Nagai Hideaki, Ooshima Nobuharu, Motegi Mitsuru, Umeda Akira, Miyagawa Kazuya, Shimada Hisato, Endo Mayu, Ohira Yoshiyuki, Sagara Hironori, Tanaka Akihiko, Ohta Shin, Kimura Tomoyuki, Shibata Yoko, Tanino Yoshinori, Nikaido Takefumi, Minemura Hiroyuki, Sato Yuki, Yamada Yuichiro, Hashino Takuya, Shinoki Masato, Iwagoe Hajime, Takahashi Hiroshi, Fujii Kazuhiko, Kishi Hiroto, Ishii Tomoo, Kanai Masayuki, Imamura Tomonori, Yamashita Tatsuya, Yatomi Masakiyo, Maeno Toshitaka, Hayashi Shinichi, Takahashi Mai, Kuramochi Mizuki, Kamimaki Isamu, Tominaga Yoshiteru, Utsugi Mitsuyoshi, Ono Akihiro, Tanaka Toru, Kashiwada Takeru, Fujita Kazue, Saito Yoshinobu, Seike Masahiro, Kanai Masahiro, Saiki Ryunosuke, Nannya Yasuhito, Hyugaji Takayoshi, Shimizu Eigo, Katayama Kotoe, Imoto Seiya, Miyawaki Satoru, Takahashi Meiko, Matsuda Fumihiko, Omae Yosuke, Tokunaga Katsushi, Ueno Takafumi, Okada Yukinori, Koike Ryuji, Kimura Akinori, Miyano Satoru, Ogawa Seishi, Fukunaga Koichi, Kanai Takanori （Journal of Gastroenterology） 59 （ 3 ） 195-208 Mar. 2024
■Indigo Naturalis and Ulcerative Colitis
・Research Objective: To assess the clinical outcomes of patients with ulcerative colitis after discontinuation of indigo naturalis and to identify potential markers responsible for relapse.
- Title: Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis, Shimada Fumie, Yoshimatsu Yusuke, Sujino Tomohisa, Fukuda Tomohiro, Aoki Yasuhiro, Hayashi Yukie, Tojo Anna, Kawaguchi Takaaki, Kiyohara Hiroki, Sugimoto Shinya, Nanki Kosaku, Mikami Yohei, Miyamoto Kentaro, Takabayashi Kaoru, Hosoe Naoki, Kato Motohiko, Ogata Haruhiko, Naganuma Makoto, Kanai Takanori （Scientific Reports） 14 （ 1 ） Mar. 2024
■Video Capsule Endoscopy and OGIB
・Research Objective: To evaluate the use of video capsule endoscopy in patients with obscure gastrointestinal bleeding and identify predictive markers of positive findings.
- Title: Video capsule endoscopy in overt and occult obscure gastrointestinal bleeding: Insights from a single‐center, observational study in Japan, Tojo Anna, Sujino Tomohisa, Hayashi Yukie, Kamiya Kenji J L Limpias, Sato Moe, Hinako Sakurai, Yoshimatsu Yusuke, Kinoshita Satoshi, Kiyohara Hiroki, Mikami Yohei, Takabayashi Kaoru, Kato Motohiko, Ogata Haruhiko, Kanai Takanori, Hosoe Naoki （DEN Open） 4 （ 1 ） Apr. 2024
■5-ASA and Dose Escalation
・Research Objective: To evaluate the therapeutic efficacy of proactive dose escalation of oral 5-aminosalicylic acid in ulcerative colitis patients with a Mayo endoscopic subscore of 1.
- Title: Efficacy of Dose Escalation of Oral 5-Aminosalicylic Acid for Ulcerative Colitis With a Mayo Endoscopic Subscore of 1: An Open Label Randomized Controlled Trial, Fukuda Tomohiro, Aoki Yasuhiro, Kiyohara Hiroki, Yokoyama Ayumi, Nakazawa Atsushi, Yoshimatsu Yusuke, Sugimoto Shinya, Nanki Kosaku, Mikami Yohei, Fukuhara Kayoko, Mizuno Shinta, Sujino Tomohisa, Mutaguchi Makoto, Takabayashi Kaoru, Morohoshi Yuichi, Hosoda Yasuo, Ogata Haruhiko, Iwao Yasushi, Naganuma Makoto, Kanai Takanori （Inflammatory Bowel Diseases） 31 （ 3 ） 716-724 Mar. 2025
■Endoscopic Submucosal Dissection and Safety
・Research Objective: To investigate the short-term outcome

Areas of Research

・Regulatory T Cells and Immune Regulation
・Leptin and Metabolic Pathways
・Intestinal and Liver Diseases
・Colitis and Inflammatory Bowel Disease
・Gastrointestinal Endoscopy and Imaging
・Neural and Immune Interactions
・Dental and Oral Health
・Inflammatory and Immune Responses
・Cellular and Molecular Mechanisms
・Endoscopic Interventions and Procedures
・Metabolic and Hypoxic Adaptations
・Therapeutic Efficacy and Safety
・Innate Lymphoid Cells and Cytokines
・Genetic and Protein Expression
・Cytotoxic T Cells and Immune Responses
・Hydrogen Gas and Oxidative Stress
・Venous Thromboembolism and Risk Factors
・Ulcerative Colitis and Inflammation
・Human Gut Cell Atlas and Research Integration
・Ulcerative Colitis and Neoplasia
・Intestinal Epithelial Cells and Gene Expression
・Microbiota and Immune System Interactions
・T Cell Induction and Hypoxic Environments
・Amino Acids and Gut Microbiota
・Gastrointestinal Symptoms and COVID-19
・Indigo Naturalis and Ulcerative Colitis
・Video Capsule Endoscopy and OGIB
・5-ASA and Dose Escalation
・Endoscopic Submucosal Dissection and Safety
・Ulcerative Colitis and Neoplasia Components
・Bile Acids and Microbiota
・Novel Perfusion Systems
・Tryptophan Metabolites and Health
・Endoscopic Mucosal Resection and Safety
・Environmental Factors and Tumors
・Endoscopic Submucosal Dissection and ERCP
・Bacterial D-amino Acids and Immune Systems

Social Contributions

・The research enhances understanding of the intestinal microenvironment and the role of regulatory T cells, aiding in the prevention of inflammatory bowel diseases.
・The findings on regulatory T cells' role in inflammation suppression within intestinal villi are crucial for developing treatments for inflammatory bowel diseases.
・The research on genetic regulation of anti-inflammatory intestinal epithelial cells could lead to new treatments for inflammatory bowel diseases.